LCE3B-E Inhibitors
LCE3B-E inhibitors are a class of chemicals that can potentially inhibit the function of the LCE3B-E protein. LCE3B-E is a member of the late cornified envelope (LCE) gene cluster, which encodes proteins involved in the formation of the cornified cell envelope, a structure important for the barrier function of the skin. The specific function of LCE3B-E is not well characterized. The inhibitors of LCE3B-E can act directly on the protein or indirectly by influencing signaling pathways or cellular processes involved in its regulation. Some of the direct inhibitors include Retinoic Acid, all trans, which can affect gene expression by binding to retinoic acid receptors, and Curcumin, which can modulate signaling pathways such as NF-κB and MAPK. Indirect inhibitors of LCE3B-E can target signaling pathways that are potentially involved in its regulation. For example, Rapamycin can inhibit the mTOR signaling pathway, which may have downstream effects on cellular processes involving LCE3B-E. SB 203580 can selectively inhibit p38 MAPK, which can indirectly influence the activity or expression of LCE3B-E. U0126 can inhibit MEK1/2, upstream kinases in the MAPK pathway, potentially disrupting MAPK signaling and affecting LCE3B-E regulation.
Other indirect inhibitors include Wortmannin, which targets the PI3K signaling pathway, and MG-132 [Z-Leu- Leu-Leu-CHO], a proteasome inhibitor that can increase the stability and expression of LCE3B-E. Cisplatin can induce DNA damage, potentially affecting gene expression, including LCE3B-E. Trichostatin A, a histone deacetylase inhibitor, can modulate chromatin structure and gene expression. Fluorouracil interferes with DNA synthesis, potentially disrupting gene expression, including LCE3B-E. Lastly, Caffeic acid phenethyl ester and DL-Sulforaphane are natural compounds that can modulate signaling pathways such as NF-κB and MAPK, potentially influencing the regulation of LCE3B-E. In summary, LCE3B-E inhibitors are a diverse group of chemicals that can directly target the protein or indirectly influence its regulation through signaling pathways or cellular processes. These inhibitors provide valuable tools for studying the function and regulation of LCE3B-E in various biological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid, all trans is a derivative of vitamin A that can potentially inhibit LCE3B-E by affecting gene expression. It can bind to retinoic acid receptors (RARs) and modulate transcriptional activity, potentially influencing the expression of LCE3B-E. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is a natural compound found in turmeric that can potentially inhibit LCE3B-E by modulating signaling pathways. It can target multiple signaling pathways, such as NF-κB and MAPK, which may be involved in the regulation of LCE3B-E. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin is an immunosuppressive agent that can potentially inhibit LCE3B-E by targeting the mTOR signaling pathway. It specifically inhibits the mTOR complex 1 (mTORC1), which may have downstream effects on cellular processes involving LCE3B-E. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a selective inhibitor of p38 MAPK, a signaling pathway that can potentially regulate LCE3B-E. By inhibiting p38 MAPK, SB203580 may indirectly influence the activity or expression of LCE3B-E. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a fungal metabolite that can potentially inhibit LCE3B-E by targeting the PI3K signaling pathway. It specifically inhibits PI3K, which may have downstream effects on cellular processes involving LCE3B-E. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 [Z-Leu- Leu-Leu-CHO] is a proteasome inhibitor that can potentially inhibit LCE3B-E by blocking protein degradation. By inhibiting the proteasome, MG-132 can potentially increase the stability and expression of LCE3B-E. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $76.00 $216.00 | 101 | |
Cisplatin is a chemotherapeutic agent that can potentially inhibit LCE3B-E by inducing DNA damage. It forms covalent adducts with DNA, leading to DNA crosslinking and potential disruption of gene expression, including LCE3B-E. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase (HDAC) inhibitor that can potentially inhibit LCE3B-E by modulating chromatin structure and gene expression. By inhibiting HDACs, Trichostatin A can increase histone acetylation and potentially affect the expression of LCE3B-E. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
5-Fluorouracil is a chemotherapeutic drug that can potentially inhibit LCE3B-E by interfering with DNA synthesis. It is incorporated into DNA and RNA, leading to the inhibition of nucleotide synthesis and potential disruption of gene expression, including LCE3B-E. | ||||||
Caffeic acid phenethyl ester | 104594-70-9 | sc-200800 sc-200800A sc-200800B | 20 mg 100 mg 1 g | $70.00 $290.00 $600.00 | 19 | |
Caffeic acid phenethyl ester is a natural compound found in propolis that can potentially inhibit LCE3B-E by modulating signaling pathways. It can target various signaling pathways, such as NF-κB and MAPK, which may be involved in the regulation of LCE3B-E. | ||||||