LCE2B Inhibitors
LCE2B inhibitors encompass a variety of chemical entities that suppress the activity of the LCE2B protein by interfering with specific signaling pathways that regulate its expression. Curcumin, for instance, inhibits the NF-κB pathway by preventing the degradation of IκBα, thus leading to reduced transcriptional activity of NF-κB and subsequently lower LCE2B expression. Parthenolide acts similarly, binding to IκB kinase and blocking NF-κB translocation to the nucleus, diminishing LCE2B levels. Aspirin contributes to this reduction by acetylating COX enzymes, decreasing prostaglandin levels, and thus lessening prostaglandin-induced NF-κB activation, which would otherwise upregulate LCE2B. Further contributing to the inhibition of LCE2B are Resveratrol and Sulforaphane, which impede the phosphorylation and degradation of IκBα, and Quercetin, which also blocks NF-κB activation by inhibiting IκBα phosphorylation. Ebselen, by inhibiting IκB kinase, and Bay 11-7082, by preventing IκBα phosphorylation, both serve to attenuate NF-κB-mediated LCE2B expression. In addition, Epigallocatechin gallate (EGCG) can suppress NF-κB, leading to downregulation of LCE2B.
Additionally, Capsaicin inhibits NF-κB activation, which contributes to the regulation of LCE2B expression, while Pyrrolidinedithiocarbamic acid ammonium salt exerts its inhibitory effect by chelating metals necessary for IκB kinase activity, stabilizing IκB, and therefore limiting NF-κB's ability to boost LCE2B expression. Chelerythrine similarly inhibits NF-κB by targeting IκB kinase, and Celastrol disrupts NF-κB activation by various mechanisms, including heat shock protein 90 (Hsp90) inhibition, which is crucial for the proper function of several signaling proteins, including those involved in the NF-κB pathway. Through these multifaceted mechanisms, these chemical inhibitors collectively achieve a decrease in LCE2B activity by modulating the pathways that govern its expression, ensuring an integrated approach to the indirect inhibition of the LCE2B protein.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can inhibit the NF-κB pathway by preventing the degradation of its inhibitor IκBα, leading to diminished transcriptional activity of NF-κB. Since LCE2B is upregulated by NF-κB during inflammatory responses, curcumin indirectly inhibits the functional activity of LCE2B by impeding the pathway that enhances its expression. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide is known to inhibit the NF-κB pathway by directly binding to and inhibiting IκB kinase, thus blocking the nuclear translocation of NF-κB. This action would result in a decreased expression of NF-κB target genes, including LCE2B, thereby indirectly reducing LCE2B protein levels. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $41.00 | 4 | |
Aspirin acetylates cyclooxygenase enzymes (COX-1 and COX-2), leading to a reduction in prostaglandin synthesis. Prostaglandins can activate the NF-κB pathway, which in turn can induce LCE2B expression. Therefore, aspirin could indirectly lead to the decreased functional activity of LCE2B by reducing prostaglandin-mediated NF-κB activation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol has been shown to inhibit the NF-κB pathway by preventing the phosphorylation and degradation of IκBα. This inhibitory action on NF-κB can lead to reduced expression of LCE2B, whose gene is a downstream target of NF-κB, thereby leading to diminished protein function. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane can inhibit the NF-κB pathway by preventing the degradation of IκBα, thus impeding the transcriptional activity of NF-κB. Since LCE2B expression is regulated by NF-κB, the inhibition of this pathway by sulforaphane leads to an indirect decrease in LCE2B activity. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin inhibits the phosphorylation of IκBα, consequently blocking NF-κB activation. By impeding NF-κB signaling, quercetin indirectly reduces the expression of NF-κB-responsive genes, including LCE2B, thereby decreasing the functional activity of the LCE2B protein. | ||||||
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $32.00 $133.00 $449.00 | 5 | |
Ebselen is an inhibitor of several enzymes, including IκB kinase, and can prevent the activation of NF-κB. By inhibiting the pathway responsible for the induction of LCE2B expression, ebselen indirectly leads to decreased LCE2B activity by reducing its expression. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
Bay 11-7082 inhibits the NF-κB pathway by blocking the phosphorylation of IκBα, resulting in the attenuation of NF-κB-driven gene expression. As a result, the expression of NF-κB target genes, such as LCE2B, is diminished, leading to an indirect reduction in LCE2B activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG can inhibit the activation of NF-κB, leading to a downregulation of its target genes. This action results in an indirect inhibition of LCE2B expression and activity, as LCE2B is among the genes that are upregulated by NF-κB in response to certain stimuli. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin has been shown to inhibit NF-κB activation by preventing IκB degradation. As this pathway is involved in the upregulation of LCE2B expression, the inhibition of NF-κB by capsaicin indirectly leads to decreased LCE2B activity. | ||||||