Laminin β-2 Inhibitors
Laminin β-2 inhibitors belong to a class of chemical compounds designed to selectively target and modulate the activity of the laminin β-2 subunit. Laminin β-2 is a component of the laminin protein, an essential glycoprotein found in the extracellular matrix of various tissues. It plays a crucial role in cell adhesion, migration, and tissue organization, particularly in structures such as the kidney glomerulus and the inner ear. Laminin β-2 inhibitors are specifically developed to interfere with the functions of laminin β-2, which may involve disrupting cell-matrix interactions or altering the organization of the extracellular matrix.
These inhibitors provide valuable tools for researchers to explore the complex biology of laminin β-2 and its contributions to cellular processes and tissue development. By studying laminin β-2 inhibitors, scientists can gain insights into the regulatory mechanisms that govern cell adhesion and migration, contributing to a better understanding of tissue homeostasis and disease pathology. Continued research in this area may lead to further discoveries about laminin β-2-related biology and its implications in various physiological and pathological conditions.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Blebbistatin disrupts myosin II-mediated cellular functions, inhibiting Laminin β-2 mediated cell migration and adhesion by altering cytoskeletal dynamics and cell contractility. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 inhibits the MAPK/ERK pathway, disrupting signaling in cell differentiation and survival, reducing Laminin β-2's effectiveness in mediating cellular responses. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002, a potent inhibitor of the PI3K/Akt pathway, reduces integrin-mediated signaling and cellular adhesion, indirectly inhibiting Laminin β-2's role. | ||||||
Batimastat | 130370-60-4 | sc-203833 sc-203833A | 1 mg 10 mg | $179.00 $377.00 | 24 | |
Batimastat inhibits matrix metalloproteinases, impeding extracellular matrix remodeling, and indirectly inhibiting Laminin β-2 in cell migration and adhesion. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin disrupts PI3K, and its downstream signaling pathways, indirectly inhibiting Laminin β-2's role in cell survival and migration. | ||||||
Marimastat | 154039-60-8 | sc-202223 sc-202223A sc-202223B sc-202223C sc-202223E | 5 mg 10 mg 25 mg 50 mg 400 mg | $168.00 $218.00 $404.00 $629.00 $4900.00 | 19 | |
Marimastat impedes extracellular matrix remodeling, crucial for Laminin β-2's role in cell migration and adhesion, thus indirectly inhibiting it. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
NSC23766 inhibits Rac1, disrupting cell motility and adhesion, indirectly inhibiting Laminin β-2's role in these processes. | ||||||
BAPTA/AM | 126150-97-8 | sc-202488 sc-202488A | 25 mg 100 mg | $138.00 $458.00 | 61 | |
BAPTA-AM, a calcium chelator, disrupts calcium-dependent signaling, indirectly inhibiting Laminin β-2's functional activity. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
ML7 inhibits MLCK, disrupting myosin-driven cell contractility and motility, crucial for Laminin β-2-mediated cell adhesion and migration. | ||||||
CCG-1423 | 285986-88-1 | sc-205241 sc-205241A | 1 mg 5 mg | $30.00 $90.00 | 8 | |
CCG-1423 inhibits the RhoA signaling pathway, crucial for cytoskeletal dynamics, indirectly inhibiting Laminin β-2's role in cell migration and adhesion. | ||||||