LAGE-1 Activators
LAGE-1, a member of the cancer/testis antigen (CT antigen) family, is a protein encoded by the LAGE-1 gene and is predominantly expressed in normal testicular germ cells and various cancer types. Functionally, LAGE-1 is implicated in tumor progression and immune evasion, although the precise molecular mechanisms remain incompletely elucidated. Despite its restricted expression pattern, LAGE-1 has garnered attention as a target for cancer immunotherapy due to its association with malignant transformation and evasion of immune surveillance. Activation of LAGE-1 is often associated with oncogenic processes, including enhanced tumor cell survival, proliferation, and immune escape mechanisms.
Activation of LAGE-1 may occur through various mechanisms, including transcriptional upregulation, post-translational modifications, and altered protein-protein interactions. Transcriptional activation of the LAGE-1 gene can be mediated by factors such as oncogenic transcription factors or epigenetic modifications that enhance gene expression. Additionally, post-translational modifications, such as phosphorylation or ubiquitination, may modulate LAGE-1 protein stability or activity, leading to its activation. Furthermore, interactions with other cellular proteins or signaling pathways implicated in tumor growth and immune evasion may contribute to the activation of LAGE-1. Overall, understanding the diverse mechanisms underlying LAGE-1 activation is critical for elucidating its role in cancer progression and devising strategies to target this protein for intervention.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly stimulates adenylyl cyclase, increasing cAMP levels, which may lead to the phosphorylation and activation of proteins through the cAMP-dependent protein kinase A (PKA) pathway. If LAGE-1 is subject to regulation by PKA, increased cAMP could result in LAGE-1 activation. | ||||||
Ionomycin, free acid | 56092-81-0 | sc-263405 sc-263405A | 1 mg 5 mg | $94.00 $259.00 | 2 | |
Ionomycin is a calcium ionophore which elevates intracellular calcium levels. Elevated calcium may activate calmodulin-dependent kinase, which could potentially phosphorylate and activate LAGE-1 if it is subject to calcium/calmodulin-dependent regulation. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA activates protein kinase C (PKC), which could phosphorylate LAGE-1 directly if it has PKC consensus sites, or influence downstream pathways leading to LAGE-1 activation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that increases cAMP levels via activation of adenylyl cyclase, similar to forskolin, and could thereby activate LAGE-1 through the PKA pathway. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $153.00 $1224.00 $12239.00 | 82 | |
Insulin activates the insulin receptor, triggering the PI3K/Akt pathway, which might phosphorylate and activate LAGE-1 if it is downstream or part of this signaling pathway. | ||||||
Hydrogen Peroxide | 7722-84-1 | sc-203336 sc-203336A sc-203336B | 100 ml 500 ml 3.8 L | $30.00 $60.00 $93.00 | 27 | |
Hydrogen peroxide acts as a signaling molecule that can modulate kinase activity. It could activate LAGE-1 through oxidative stress-mediated signaling pathways if LAGE-1 is sensitive to redox regulation. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $97.00 $254.00 | 36 | |
Anisomycin is a JNK activator which could lead to the activation of LAGE-1 if it is regulated by JNK signaling pathways. | ||||||
Sodium Fluoride | 7681-49-4 | sc-24988A sc-24988 sc-24988B | 5 g 100 g 500 g | $39.00 $45.00 $98.00 | 26 | |
Sodium fluoride is an activator of heterotrimeric G proteins, which could influence multiple signaling pathways, potentially leading to LAGE-1 activation if it interacts with G protein-coupled pathways. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid modulates gene expression through its receptors. If LAGE-1 is influenced by retinoic acid receptor signaling, this could result in its activation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $45.00 $130.00 $480.00 $4450.00 | 74 | |
Dibutyryl-cAMP is a cell-permeable cAMP analog that activates PKA. If LAGE-1 is a PKA substrate, this could lead to its direct activation. | ||||||