KRTAP5-7 Activators
KRTAP5-7 play a pivotal role in modulating the function of this hair shaft reinforcement protein through various biochemical pathways. Phorbol 12-myristate 13-acetate (PMA) and 12-O-Tetradecanoylphorbol-13-acetate (TPA) both activate protein kinase C (PKC), a key player in the phosphorylation of many proteins including KRTAP5-7. Activation of PKC leads to the phosphorylation of KRTAP5-7, thereby enhancing its function in the hair shaft. Similarly, Bryostatin 1, through its interaction with PKC, and Phosphatidylserine, by modulating PKC activity, can also facilitate the phosphorylation and subsequent activation of KRTAP5-7. Forskolin and Dibutyryl-cAMP elevate intracellular cAMP levels, which in turn activate protein kinase A (PKA). PKA is another kinase that can target KRTAP5-7, leading to its phosphorylation and activation.
Ionomycin and Thapsigargin alter calcium concentrations within cells, which can initiate the activation of calcium-dependent kinases that may target KRTAP5-7. Ionomycin, being a calcium ionophore, increases intracellular calcium levels, while Thapsigargin disrupts calcium homeostasis by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA). Both of these alterations in calcium signaling can lead to the activation of KRTAP5-7. In addition, Calyculin A and Okadaic Acid, by inhibiting protein phosphatases PP1 and PP2A, prevent the dephosphorylation of KRTAP5-7, thereby maintaining it in an active phosphorylated state. Cantharidin, another protein phosphatase inhibitor, operates via a similar mechanism to sustain the active form of KRTAP5-7. Retinoic Acid, though not directly involved in phosphorylation, can influence cellular differentiation processes that may upregulate enzymes responsible for KRTAP5-7 activation. These chemical activators collectively ensure that KRTAP5-7 retains its functional phosphorylation, crucial for its role in reinforcing the hair shaft structure.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which is known to phosphorylate a variety of protein substrates including keratin-associated proteins (KAPs) such as KRTAP5-7, thereby increasing their function in hair shaft reinforcement. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
As an inhibitor of protein phosphatases PP1 and PP2A, Calyculin A indirectly sustains the phosphorylation state of proteins. Phosphorylated KRTAP5-7 remains activated as part of its function in hair follicle structure. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that raises intracellular calcium levels, leading to the activation of calcium-dependent enzymes, possibly including those that modify KRTAP5-7's function in hair. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin disrupts calcium homeostasis by inhibiting the sarcoplasmic/endoplasmic reticulum Ca2+ ATPase (SERCA), which can lead to activation of calcium-dependent pathways that may result in the activation of KRTAP5-7. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
By inhibiting protein phosphatases, okadaic acid can lead to an increase in the phosphorylated forms of proteins. This could maintain KRTAP5-7 in an activated state, facilitating its structural role. | ||||||
L-α-Lecithin, Egg Yolk, Highly Purified | 8002-43-5 | sc-203096 | 250 mg | $135.00 | ||
Phosphatidylserine can modulate the activity of PKC, which might result in increased phosphorylation and activation of substrates like KRTAP5-7 involved in hair structure enhancement. | ||||||
Bryostatin 1 | 83314-01-6 | sc-201407 | 10 µg | $245.00 | 9 | |
Bryostatin 1 binds to and modulates PKC, potentially leading to the phosphorylation and activation of proteins such as KRTAP5-7, which is important for hair fiber integrity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Dibutyryl-cAMP, a cAMP analog, activates PKA, which could result in phosphorylation and activation of proteins including those like KRTAP5-7 that contribute to hair strength. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can modulate cellular differentiation pathways, possibly leading to the upregulation of enzymes that favor the activation of structural proteins like KRTAP5-7 in hair follicles. | ||||||
Cantharidin | 56-25-7 | sc-201321 sc-201321A | 25 mg 100 mg | $89.00 $279.00 | 6 | |
Cantharidin inhibits protein phosphatases, which could lead to sustained activation of proteins such as KRTAP5-7 by preventing their dephosphorylation, thus playing a role in maintaining hair structure. | ||||||