KRTAP5-7 Inhibitors
KRTAP5-7 inhibitors are compounds that target the functional activity of the Keratin Associated Protein 5-7, which plays a role in hair structure. Lithium chloride, for example, dampens the activity of GSK-3, a kinase that phosphorylates proteins integral to hair shaft structure. The inhibition of GSK-3 could subsequently impede the correct incorporation of KRTAP5-7 with other hair-associated proteins, leading to a decrease in its functionality. Similarly, staurosporine broadly targets protein kinases, which may inhibit the phosphorylation and activation of proteins that regulate the assembly of keratins and keratin-associated proteins, such as KRTAP5-7. This broad-spectrum kinase inhibition could result in a reduction of KRTAP5-7's functional activity within the hair follicle.
Moreover, the mTOR pathway, a key regulator of protein synthesis, can be inhibited by rapamycin. This inhibition could result in a decreased synthesis of proteins necessary for KRTAP5-7's role in the hair follicle, indirectly reducing KRTAP5-7 activity. Cycloheximide, which blocks eukaryotic protein translation, would similarly reduce the available KRTAP5-7 protein, affecting its function. U0126 and PD98059, both MEK inhibitors, reduce the phosphorylation of ERK in the MAPK pathway which is associated with keratinocyte differentiation, potentially leading to decreased functional activity of KRTAP5-7. LY294002 and wortmannin are PI3K/Akt pathway inhibitors which could lead to reduced synthesis or activity of proteins that interact with KRTAP5-7. SP600125 inhibits JNK, potentially destabilizing proteins important for KRTAP5-7 function. SB203580 specifically targets p38 MAPK, implicated in responses that affect keratin protein stability and expression, possibly reducing KRTAP5-7 activity. Chelerythrine chloride inhibits PKC, which is involved in hair follicle structure formation and could affect the role of KRTAP5-7 in this process. Finally, roscovitine, a CDK inhibitor, may disrupt cell cycle progression and differentiation in keratinocytes, which could inhibit the proper integration of KRTAP5-7 into hair structures.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can indirectly inhibit KRTAP5-7 by acting on glycogen synthase kinase 3 (GSK-3). GSK-3 is a kinase that can phosphorylate various substrates, including proteins involved in the structural integrity of hair shafts. Inhibition of GSK-3 by lithium chloride may prevent the appropriate interaction of KRTAP5-7 with other hair keratin-associated proteins, leading to a decrease in its functional incorporation into the hair follicle structure. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. By broadly inhibiting protein kinases, staurosporine may prevent the phosphorylation and subsequent activation of proteins that regulate the structural assembly of keratins and keratin-associated proteins like KRTAP5-7, thereby reducing its functional activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits the mTOR signaling pathway, which is involved in protein synthesis and cell growth. By inhibiting mTOR, rapamycin can lead to reduced synthesis of proteins that are essential for the proper function of KRTAP5-7 within the hair follicle, thereby indirectly inhibiting KRTAP5-7 activity. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide is an inhibitor of eukaryotic protein translation. While it does not inhibit the transcription of KRTAP5-7, the blockage of translation will indirectly reduce the amount of KRTAP5-7 protein available for incorporation into the hair follicle structure, thus inhibiting its function. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a selective inhibitor of MEK1/2, which are upstream of ERK in the MAPK pathway. By inhibiting this pathway, U0126 can reduce the phosphorylation of downstream targets that may be involved in the functional regulation of KRTAP5-7, leading to a decrease in KRTAP5-7 activity. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is an inhibitor of the PI3K/Akt pathway. This pathway is involved in various cellular processes, including protein synthesis. Inhibition of PI3K/Akt by LY294002 can lead to decreased activity of proteins that interact with or regulate KRTAP5-7, resulting in reduced functional activity of KRTAP5-7. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, which modulates cellular processes such as protein stability. By inhibiting JNK, SP600125 may destabilize proteins that are necessary for the structural integrity and function of KRTAP5-7, leading to its functional inhibition. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAPK. The p38 MAPK pathway is implicated in stress responses, including the response to UV light, which can impact keratin and keratin-associated protein expression and function. Inhibition of p38 MAPK by SB203580 may reduce the stability or expression of proteins that are required for KRTAP5-7 function. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that prevents the activation of ERK, which is part of the MAPK pathway. By inhibiting ERK activation, PD98059 can decrease the phosphorylation of substrates involved in keratinocyte differentiation, potentially inhibiting the functional activity of KRTAP5-7. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a potent inhibitor of PI3K. It can lead to decreased activity of the Akt pathway, which is involved in cell survival and protein synthesis. Reduced activity of this pathway by wortmannin can indirectly inhibit the function of KRTAP5-7 by decreasing the synthesis of associated structural proteins. | ||||||