KRTAP19-6 Inhibitors
KRTAP19-6 inhibitors are chemical compounds designed to interact with and inhibit the function of keratin-associated protein 19-6 (KRTAP19-6), a member of the keratin-associated protein family. These proteins are essential components in the structure and stabilization of keratin fibers, particularly in hair and epithelial tissues. KRTAP19-6 plays a role in the formation of the complex protein matrices that are critical for maintaining hair's strength, structure, and resilience. Inhibitors of KRTAP19-6 target its function by disrupting the interactions between this keratin-associated protein and keratin itself, potentially leading to alterations in the mechanical properties of hair or keratinized tissues.
Structurally, KRTAP19-6 inhibitors are designed to bind to specific active sites or domains of the protein, thereby preventing its normal function in keratin matrix assembly. These inhibitors typically have high specificity, relying on their ability to selectively engage with the unique molecular structure of KRTAP19-6, which is characterized by its unique protein domains. This specificity reduces off-target effects on other keratin-associated proteins or related cellular functions. KRTAP19-6 inhibitors often possess a diverse range of chemical scaffolds, enabling them to fine-tune their binding affinity and stability within biological environments. The design of these molecules takes into account key physicochemical properties such as solubility, molecular weight, and binding kinetics to ensure they effectively modulate the function of KRTAP19-6 without affecting the broader proteomic landscape within the keratinized tissues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This agent could hypothetically decrease KRTAP19-6 expression by incorporating into DNA and RNA, leading to the hypomethylation of gene promoter regions, subsequently reducing transcription. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
By inhibiting histone deacetylase, Trichostatin A could lead to hyperacetylation of histones, which might result in a compact chromatin structure that downregulates KRTAP19-6 gene expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid could decrease KRTAP19-6 expression by binding to retinoic acid receptors, which can bind to the promoter region of the gene and suppress its transcription. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin could inhibit the mTOR signaling pathway, leading to reduced transcriptional and translational activity for various genes including KRTAP19-6. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide could inhibit the translocation step in protein synthesis, potentially leading to a general decrease in protein levels, including KRTAP19-6. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
This compound could bind to DNA and inhibit the RNA polymerase enzyme, resulting in the downregulation of KRTAP19-6 by preventing its mRNA synthesis. | ||||||
Hydralazine-15N4 Hydrochloride | 304-20-1 (unlabeled) | sc-490605 | 1 mg | $480.00 | ||
Hydralazine may reduce KRTAP19-6 expression by decreasing DNA methylation globally, which could lead to the suppression of gene transcription. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin could decrease KRTAP19-6 expression by inhibiting the activation of NF-κB, a transcription factor that may be necessary for the transcription of the KRTAP19-6 gene. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
By activating sirtuin 1, Resveratrol could lead to the deacetylation of transcription factors and histones, potentially resulting in the downregulation of KRTAP19-6 expression. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate could inhibit dihydrofolate reductase, which may lead to a depletion of nucleotide precursors and a consequent decrease in KRTAP19-6 transcription. | ||||||