KRT222 Activators
Keratin 222 (KRT222) is part of the keratin family, a diverse group of structural proteins that are key components of the intermediate filament network in epithelial cells. Keratins are known for their structural role in providing mechanical stability and resilience to cells and tissues. They are divided into two types: type I (acidic) and type II (basic to neutral), which form heterodimers and then polymers to create the intermediate filament network. KRT222, specifically, falls within this broad family, contributing to the structural integrity and function of epithelial cells.
Activators of KRT222, if they were characterized, would be chemical compounds or molecules that specifically enhance or modulate the function or expression of KRT222. These activators might operate by interacting at the genetic level to increase the transcription of the KRT222 gene, or at the protein level to stabilize the keratin filament network, enhancing its structural properties. In the context of cellular biology, the regulation of keratin expression and function is crucial for maintaining the proper structure and resilience of epithelial tissues.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
All-trans retinoic acid, through its nuclear receptors, could modulate the transcription of genes, including those encoding keratins. | ||||||
Hydrocortisone | 50-23-7 | sc-300810 | 5 g | $102.00 | 6 | |
Hydrocortisone, a glucocorticoid, might influence gene expression in epithelial cells, potentially affecting keratin expression. | ||||||
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $220.00 $645.00 $1000.00 $1500.00 $440.00 | 32 | |
The active form of vitamin D3 might regulate differentiation-related gene expression in keratinocytes, including keratins. | ||||||
Methyl-β-cyclodextrin | 128446-36-6 | sc-215379A sc-215379 sc-215379C sc-215379B | 100 mg 1 g 10 g 5 g | $20.00 $48.00 $160.00 $82.00 | 19 | |
Methyl-β-cyclodextrin could alter membrane cholesterol, indirectly modulating signaling pathways that influence keratin expression. | ||||||
13-cis-Retinoic acid | 4759-48-2 | sc-205568 sc-205568A | 100 mg 250 mg | $75.00 $120.00 | 8 | |
As a retinoid, isotretinoin might affect keratinocyte differentiation and potentially regulate keratin gene expression. | ||||||
Dimethyl Sulfoxide (DMSO) | 67-68-5 | sc-202581 sc-202581A sc-202581B | 100 ml 500 ml 4 L | $31.00 $117.00 $918.00 | 136 | |
DMSO is known to induce differentiation in certain cell types, which could theoretically affect the expression of keratin genes. | ||||||
Sodium arsenite, 0.1N Standardized Solution | 7784-46-5 | sc-301816 | 500 ml | $130.00 | 4 | |
Exposure to sodium arsenite can induce a cellular stress response, potentially leading to changes in keratin expression. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
Tunicamycin inhibits N-linked glycosylation, leading to stress responses that might alter keratin gene expression. | ||||||
Butylated hydroxyanisole | 25013-16-5 | sc-252527 sc-252527A | 5 g 100 g | $30.00 $98.00 | 1 | |
BHA could influence oxidative stress responses in cells, potentially affecting keratin gene expression. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $94.00 $213.00 | 33 | |
Methotrexate affects cellular proliferation and differentiation, which might result in changes in keratin expression. | ||||||