Molecular structure of 13-cis-Retinoic acid, CAS Number: 4759-48-2
13-cis-Retinoic acid (CAS 4759-48-2)
See product citations (8)
Alternate Names:
Isotretinoin; Accutane; Amnesteem; Claravis
Application:
13-cis-Retinoic acid is a vitamin A analog that inhibits cell proliferation
CAS Number:
4759-48-2
Purity:
≥98%
Molecular Weight:
300.44
Molecular Formula:
C20H28O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
13-cis-Retinoic acid is a compound studied in the field of biochemistry for its role in cellular differentiation and proliferation. In research, it is often used as a tool to understand the signaling pathways regulated by retinoids, which are critical for vertebrate development and tissue maintenance. Scientists utilize this compound to investigate the mechanisms of gene expression modulation, as it is known to bind to retinoic acid receptors and retinoid X receptors, influencing transcription processes. In dermatological research, it is of particular interest due to its effects on skin cell growth and differentiation, providing insights into the underlying molecular mechanisms of skin development and regeneration.
13-cis-Retinoic acid (CAS 4759-48-2) References
- Biotransformation of 13(Z)-retinoic acid in mouse skin and human keratinocyte cultures. | Chang, HC. and Samokyszyn, VM. 2000. Kaohsiung J Med Sci. 16: 387-92. PMID: 11221542
- Cellular metabolism and actions of 13-cis-retinoic acid. | Blaner, WS. 2001. J Am Acad Dermatol. 45: S129-35. PMID: 11606944
- 13-cis-retinoic acid and cancer chemoprevention. | Lippman, SM. and Hong, WK. 1992. J Natl Cancer Inst Monogr. 111-5. PMID: 1389684
- Acne fulminans and 13-cis-retinoic acid. | Choi, EH. and Bang, D. 1992. J Dermatol. 19: 378-83. PMID: 1401493
- 13-cis-retinoic acid is an endogenous compound in human serum. | Tang, GW. and Russell, RM. 1990. J Lipid Res. 31: 175-82. PMID: 2324641
- Hydroperoxide-dependent cooxidation of 13-cis-retinoic acid by prostaglandin H synthase. | Samokyszyn, VM. and Marnett, LJ. 1987. J Biol Chem. 262: 14119-33. PMID: 3115987
- Hypercalcemia is a frequent side effect of 13-cis-retinoic acid treatment in patients with high-risk neuroblastoma. | Hoemberg, M., et al. 2022. Pediatr Blood Cancer. 69: e29374. PMID: 34569150
- Determination of 13-cis-Retinoic Acid and Its Metabolites in Plasma by Micellar Electrokinetic Chromatography Using Cyclodextrin-Assisted Sweeping for Sample Preconcentration. | Huang, YX., et al. 2021. Molecules. 26: PMID: 34641409
- Chronic Administration of 13-cis-retinoic Acid Induces Depression-Like Behavior by Altering the Activity of Dentate Granule Cells. | Su, XH., et al. 2022. Neurotherapeutics. 19: 421-433. PMID: 34893965
- 13‑cis‑retinoic acid inhibits the self‑renewal, migration, invasion and adhesion of cholangiocarcinoma cells. | Butsri, S., et al. 2023. Int J Mol Med. 51: PMID: 36660943
- 13-Cis-retinoic acid: pharmacology, toxicology, and clinical applications for the prevention and treatment of human cancer. | Meyskens, FL., et al. 1985. Crit Rev Oncol Hematol. 3: 75-101. PMID: 3893773
- 13-cis-retinoic acid and bone density. | Kocijancic, M. 1995. Int J Dermatol. 34: 733-4. PMID: 8537167
- Regiospecificity of peroxyl radical addition to (E)-retinoic acid. | Samokyszyn, VM., et al. 1997. Chem Res Toxicol. 10: 795-801. PMID: 9250414
Inhibitor of:
17β-HSD8, ACAD-8, apoA-V, BHLHB4, CRBP I, CRBP II, CRBP III, CYP26, CYP26A1, CYP27B1, CYP4F22, DHRS2, DHRS3, DHRS4L2, DHRS7B, HoxB1, Ichthyin, Keratin 75, KRTAP10-2, KRTAP10-9, LCE2D, LRAT, Olr235, OPN1LW, PNPLA1, PTPLB, RAI16, RAI2, RAI3, RARα1, Rarres1, RBP2, RDH1, RDH10, RDH12, RDH14, RDH16, RDH19, RDH7, RDH9, Retinal RX, RETSAT, RGR, Rhodopsin, SPINK9, and tropoelastin.Activator of:
A1-b, BMP-10, BMPR-IB, CCDC48, CD1, CRABP-I, CRABP-II, CRALBP, CRBP III, CRBP IV, CtBP1, CYP26, CYP26B1, CYP26C1, Cytokeratin 14, DDO, DHRS7B, DHRS7C, DHRS9, DSC3B, DUX, EF-CBP1, Elastase-3B, EVI2B, FAM69A, FLJ44635, HES7, HoxA5, HoxB2, HR, IRBP, IRX2, KCP3, Keratin 28, Keratin 6B, KIAA2022, KRT222, KRTAP13-2, KRTAP15-1, LOC100039830, LOC100040682, LOC100041076, LOC100041324, NBPF15, neuropsin, NP60, NPAL3, Olfr584, Olfr585, Olfr586, OPN1MW, OR10K1, OR1M1, OR2L3, PCDHA2, PCDHGA1, PCDHGA12, PCDHGC4, PCSK9, PIG-M, PLSCR5, PPPDE1, PRRT3, QTRTD1, RAI2, RARα1, RARα2, Rarres1, RD3, RDH1, RDH11, RDH2, RDH5, RDH8, RDH9, RDHE2, Retinal RX2, robo2, RPE, Sall1, scute, Stra6, TIG3, TMEM91, VSIG8, and ZNF792.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
13-cis-Retinoic acid, 100 mg | sc-205568 | 100 mg | $75.00 | |||
13-cis-Retinoic acid, 250 mg | sc-205568A | 250 mg | $120.00 |