Kremen-2 Activators
Lithium Chloride fosters an environment where beta-catenin can accumulate, potentially compensating for Kremen-2 mediated inhibition of the signaling cascade. GSK-3 Inhibitor IX, GSK-3 Inhibitor XVI, and QS 11, provide a boost to beta-catenin signaling that can overshadow the suppressive effects Kremen-2 typically exerts on the pathway. Valproic Acid operates through a different mode, acting as an HDAC inhibitor to broaden the spectrum of gene expression, which may touch upon components of the Wnt pathway and inadvertently influence Kremen-2's function.
A direct Wnt signaling agonist creates an influx of ligands that may increase the activation of Kremen-2 by saturating its inhibitory role. Conversely, tankyrase inhibitors like XAV939 and JW55 work to stabilize Axin, thereby promoting the degradation of beta-catenin and subtly shifting the signaling equilibrium that Kremen-2 is a part of. Other compounds such as IWR-1 and IWP-2 selectively manipulate the production and activity of Wnt ligands, which can lead to an altered interaction with Kremen-2, thus affecting its activity. Similarly, Skp2 Inhibitor, C1, operates by increasing p27 levels, which may indirectly influence the cell cycle and Wnt signaling, further affecting the functional landscape of Kremen-2.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Inhibits GSK-3, leading to increased beta-catenin levels, which can compensate for Kremen-2 mediated signaling inhibition. | ||||||
GSK-3 Inhibitor IX | 667463-62-9 | sc-202634 sc-202634A sc-202634B | 1 mg 10 mg 50 mg | $57.00 $184.00 $867.00 | 10 | |
Inhibits GSK-3, promoting beta-catenin stabilization and can counteract Kremen-2's negative regulation on Wnt signaling. | ||||||
GSK-3 Inhibitor XVI | 252917-06-9 | sc-221691 sc-221691A | 5 mg 25 mg | $153.00 $520.00 | 4 | |
GSK-3 inhibitor that can enhance beta-catenin signaling, potentially overriding Kremen-2's inhibitory effects. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
HDAC inhibitor that can increase global gene expression, possibly affecting Wnt signaling components and Kremen-2's role. | ||||||
Wnt Agonist | 853220-52-7 | sc-222416 sc-222416A | 5 mg 25 mg | $154.00 $597.00 | 23 | |
Directly activates Wnt signaling, which may indirectly enhance the activity of Kremen-2 by increasing ligand availability. | ||||||
Wnt Synergist, QS11 | 944328-88-5 | sc-222417 sc-222417A | 5 mg 25 mg | $138.00 $595.00 | ||
Inhibits GSK-3, potentially increasing beta-catenin activity and influencing Kremen-2's effects. | ||||||
SB-216763 | 280744-09-4 | sc-200646 sc-200646A | 1 mg 5 mg | $70.00 $198.00 | 18 | |
GSK-3 inhibitor that can lead to increased beta-catenin signaling, possibly affecting Kremen-2 function. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $35.00 $115.00 $515.00 | 26 | |
Tankyrase inhibitor that stabilizes Axin, can lead to beta-catenin degradation, indirectly affecting Kremen-2's role. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $132.00 | 19 | |
Inhibits Wnt response by stabilizing Axin, can indirectly modulate Kremen-2's activity in the pathway. | ||||||
IWP-2 | 686770-61-6 | sc-252928 sc-252928A | 5 mg 25 mg | $94.00 $286.00 | 27 | |
Inhibits Wnt production, potentially altering Kremen-2 activity by modulating pathway ligand levels. | ||||||