Molecular structure of Wnt Agonist, CAS Number: 853220-52-7
Wnt Agonist (CAS 853220-52-7)
See product citations (23)
Alternate Names:
Wnt Agonist is also known as BML-284.
Application:
Wnt Agonist is a cell-permeable pyrimidine that functions as a potent and selective activator of Wnt signaling.
CAS Number:
853220-52-7
Purity:
≥95%
Molecular Weight:
350.37
Molecular Formula:
C19H18N4O3
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Wnt Agonist is a cell-permeable pyrimidine compound that acts as a potent and selective activator of Wnt signaling. Wnt Agonist functions best at an IC50 > 60 μM. In addition to mimicking the effect of Wnt, Wnt Agonist has also induced β-catenin and T-cell fate-dependent transcriptional activity in HEK-293T cells at an EC50 = 700 nM. When applied to Xenopous embryos, Wnt Agonist caused substantial head defects development. Wnt Agonist has also been observed to enhance beta cell expansion in vitro. Wnt Agonist is beneficial for studying the effects of Wnt pathway, due to the activation of Wnt without inhibiting the activity of GSK-3β.
Wnt Agonist (CAS 853220-52-7) References
- Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. | Gazit, A., et al. 1999. Oncogene. 18: 5959-66. PMID: 10557084
- A small-molecule agonist of the Wnt signaling pathway. | Liu, J., et al. 2005. Angew Chem Int Ed Engl. 44: 1987-90. PMID: 15724259
- Retinoid signaling can repress blastula Wnt signaling and impair dorsal development in Xenopus embryo. | Li, S., et al. 2008. Differentiation. 76: 897-907. PMID: 18452549
- Polycystin-1 C-terminal tail associates with beta-catenin and inhibits canonical Wnt signaling. | Lal, M., et al. 2008. Hum Mol Genet. 17: 3105-17. PMID: 18632682
- Identification of small-molecule inducers of pancreatic beta-cell expansion. | Wang, W., et al. 2009. Proc Natl Acad Sci U S A. 106: 1427-32. PMID: 19164755
- Pizotifen inhibits the proliferation and invasion of gastric cancer cells. | Jiang, Y., et al. 2020. Exp Ther Med. 19: 817-824. PMID: 32010241
- Exposure to Oxadiazon-Butachlor causes cardiac toxicity in zebrafish embryos. | Huang, Y., et al. 2020. Environ Pollut. 265: 114775. PMID: 32504889
- Emodin Suppresses the Migration and Invasion of Melanoma Cells. | Liu, C., et al. 2021. Biol Pharm Bull. 44: 771-779. PMID: 33731543
- Sestrin2 reduces cancer stemness via Wnt/β-catenin signaling in colorectal cancer. | Wei, J., et al. 2022. Cancer Cell Int. 22: 75. PMID: 35148781
- The NOP14 nucleolar protein suppresses the function and stemness of melanoma stem-like cells through Wnt/beta-catenin signaling inactivation. | Li, J., et al. 2022. Bioengineered. 13: 7648-7658. PMID: 35282769
- 5-HMF affects cardiovascular development in zebrafish larvae via reactive oxygen species and Wnt signaling pathways. | Jiang, Y., et al. 2022. Comp Biochem Physiol C Toxicol Pharmacol. 262: 109452. PMID: 36067963
- Bioinspired sandwich-like hybrid surface functionalized scaffold capable of regulating osteogenesis, angiogenesis, and osteoclastogenesis for robust bone regeneration. | Wu, M., et al. 2022. Mater Today Bio. 17: 100458. PMID: 36278143
- FGF9 Promotes Expression of HAS2 in Palatal Elevation via the Wnt/β-Catenin/TCF7L2 Pathway. | Sun, Y., et al. 2022. Biomolecules. 12: PMID: 36358989
- Caudatin Inhibits the Proliferation, Invasion, and Glycolysis of Osteosarcoma Cells via the Wnt/β- Catenin Pathway. | Zhang, Y., et al. 2022. Evid Based Complement Alternat Med. 2022: 4026688. PMID: 36588592
Inhibitor of:
δ-catenin, 2200002K05Rik, C1orf53, CELSR2, GPR89C, KIAA1324L, M83, Neuro D2, R-Spondin3, SPRN, and ZNF651.Activator of:
AIRE-1, Ajuba, B9D1, C16orf89, C16orf93, C17orf105, C2orf15, CCDC45, CCDC64B, CFDP1, CSNK1A1L, DAAM1, DCHS1, DnaJC18, Draxin, Evx-1, FAM181B, FOXD3, FOXF2, FOXN4, FRMD5, girdin, GPR125, GRK 7, Idax, KIAA1984, KLHL13, Kremen-2, Latrophilin-1, LNX2, LOC100365008, LOC348751, MACF1-4, MAML3, Manic Fringe, Mgat4e, MOSPD1, NEPH2, Notch 4, Olfr774, Phox2b, Radixin, RGD1560436, Ripply1, SEMA4F, Slit1, Sox-17, SPATA32, TBC1D10B, Tcam1, TEX2, THSD7B, TMEM104, TMEM107, TMEM188, Vangl1, Veli2, Wnt, Wnt-2b, and Wnt-8b.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Wnt Agonist, 5 mg | sc-222416 | 5 mg | $157.00 | |||
Wnt Agonist, 25 mg | sc-222416A | 25 mg | $609.00 |