Kremen-1 Inhibitors
Kremen-1 Inhibitors belong to a specialized chemical class that primarily targets the Kremen-1 protein, which plays a significant role in certain cellular processes. Kremen-1 is a transmembrane protein that is involved in modulating the Wnt signaling pathway, a crucial pathway in embryonic development, tissue homeostasis, and cell proliferation. Kremen-1 Inhibitors are designed to specifically interact with and inhibit the activity of Kremen-1, thereby influencing the Wnt signaling pathway.
The Wnt signaling pathway is essential for a range of biological functions, including cell differentiation, proliferation, and migration. Kremen-1 acts as a co-receptor for Wnt ligands, regulating their interaction with Frizzled receptors. By inhibiting Kremen-1, these inhibitors can modulate the Wnt signaling cascade, impacting various cellular processes. Researchers have been studying Kremen-1 Inhibitors as potential tools for investigating the fundamental mechanisms of Wnt signaling and understanding their implications in various physiological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cholesterol | 57-88-5 | sc-202539C sc-202539E sc-202539A sc-202539B sc-202539D sc-202539 | 5 g 5 kg 100 g 250 g 1 kg 25 g | $27.00 $2809.00 $129.00 $210.00 $583.00 $88.00 | 11 | |
Cholesterol modulates the activity of the Wnt signaling pathway, where Kremen-1 is a co-receptor. Altered cholesterol levels can influence the membrane distribution of Kremen-1, thus affecting its function. | ||||||
Cholecalciferol | 67-97-0 | sc-205630 sc-205630A sc-205630B | 1 g 5 g 10 g | $71.00 $163.00 $296.00 | 2 | |
Vitamin D3 has been shown to influence Wnt signaling, which could alter the expression or function of Kremen-1 indirectly by affecting the pathway's components. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin inhibits several kinases and signaling pathways, potentially influencing Kremen-1 activity indirectly by modulating Wnt signaling pathway components. | ||||||
IWR-1-endo | 1127442-82-3 | sc-295215 sc-295215A | 5 mg 10 mg | $82.00 $135.00 | 19 | |
IWR-1 stabilizes the Axin destruction complex, which can reduce β-catenin levels affecting the Kremen-1 mediated Wnt signaling pathway. | ||||||
SB-3CT | 292605-14-2 | sc-205847 sc-205847A | 1 mg 5 mg | $102.00 $388.00 | 15 | |
ICG-001 binds to CBP and disrupts its interaction with β-catenin, thereby influencing Kremen-1 activity indirectly through modulation of Wnt/β-catenin signaling. | ||||||
PF 670462 | 950912-80-8 | sc-204180 sc-204180A | 10 mg 50 mg | $198.00 $808.00 | 9 | |
PF-670462 is a CK1δ/ε inhibitor, which can affect Wnt/β-catenin signaling and indirectly modulate Kremen-1 activity. | ||||||
Salinomycin | 53003-10-4 | sc-253530 sc-253530C sc-253530A sc-253530B | 5 mg 10 mg 25 mg 100 mg | $162.00 $241.00 $406.00 $474.00 | 1 | |
Salinomycin has been shown to affect Wnt signaling by decreasing the levels of LRP6, a co-receptor with Kremen-1, thus potentially influencing Kremen-1's function. | ||||||
Niclosamide | 50-65-7 | sc-250564 sc-250564A sc-250564B sc-250564C sc-250564D sc-250564E | 100 mg 1 g 10 g 100 g 1 kg 5 kg | $38.00 $79.00 $188.00 $520.00 $1248.00 $5930.00 | 8 | |
Niclosamide can disrupt Wnt/Frizzled signaling and has been shown to reduce the levels of Wnt pathway components, which may affect Kremen-1's activity indirectly. | ||||||