Kremen-1 Antibody (R17-2): sc-74206

Kremen-1 Antibody (R17-2) is a rat monoclonal IgG2a antibody that detects Kremen-1 protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). Anti-Kremen-1 antibody (R17-2) is available as a non-conjugated format. Kremen-1 plays a crucial role as a Wnt antagonist, essential for regulating Wnt signaling pathways vital for various developmental processes, including embryogenesis and formation of the central nervous system. Through interaction with Wnt ligands, Kremen-1 helps maintain the balance of Wnt activity, ensuring appropriate modulation of developmental signals. This regulation is particularly important since aberrant Wnt signaling can lead to developmental disorders and contribute to cancer progression. Kremen-1 is primarily located on the cell surface, where Kremen-1 effectively interacts with Wnt proteins and other signaling molecules, influencing cellular responses and developmental outcomes. Kremen-1′s ability to modulate Wnt signaling highlights its significance in developmental biology and potential as a therapeutic target in diseases associated with dysregulated Wnt pathways.

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Kremen-1 Antibody (R17-2) References:

1. Isolation and biochemical characterization of the human Dkk-1 homologue, a novel inhibitor of mammalian Wnt signaling.  |  Fedi, P., et al. 1999. J Biol Chem. 274: 19465-72. PMID: 10383463
2. Expression profiling and functional analysis of wnt signaling mechanisms in mesenchymal stem cells.  |  Etheridge, SL., et al. 2004. Stem Cells. 22: 849-60. PMID: 15342948
3. Effects of parathyroid hormone on Wnt signaling pathway in bone.  |  Kulkarni, NH., et al. 2005. J Cell Biochem. 95: 1178-90. PMID: 15962290
4. Kremen is required for neural crest induction in Xenopus and promotes LRP6-mediated Wnt signaling.  |  Hassler, C., et al. 2007. Development. 134: 4255-63. PMID: 17978005
5. Genetic studies on components of the Wnt signalling pathway and the severity of joint destruction in rheumatoid arthritis.  |  de Rooy, DP., et al. 2013. Ann Rheum Dis. 72: 769-75. PMID: 23041840
6. Structure of the Dual-Mode Wnt Regulator Kremen1 and Insight into Ternary Complex Formation with LRP6 and Dickkopf.  |  Zebisch, M., et al. 2016. Structure. 24: 1599-605. PMID: 27524201
7. Recent Progress of Wnt Pathway Inhibitor Dickkopf-1 in Liver Cancer.  |  Li, J., et al. 2018. J Nanosci Nanotechnol. 18: 5192-5206. PMID: 29458569
8. DKK3 ameliorates neuropathic pain via inhibiting ASK-1/JNK/p-38-mediated microglia polarization and neuroinflammation.  |  Zhang, LQ., et al. 2022. J Neuroinflammation. 19: 129. PMID: 35658977
9. Dishevelled is a component of the frizzled signaling pathway in Drosophila.  |  Krasnow, RE., et al. 1995. Development. 121: 4095-102. PMID: 8575310
10. Wnt signaling: a common theme in animal development.  |  Cadigan, KM. and Nusse, R. 1997. Genes Dev. 11: 3286-305. PMID: 9407023
11. Dickkopf-1 is a member of a new family of secreted proteins and functions in head induction.  |  Glinka, A., et al. 1998. Nature. 391: 357-62. PMID: 9450748
12. Bridging of beta-catenin and glycogen synthase kinase-3beta by axin and inhibition of beta-catenin-mediated transcription.  |  Sakanaka, C., et al. 1998. Proc Natl Acad Sci U S A. 95: 3020-3. PMID: 9501208

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Kremen-1 Antibody (R17-2) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-Kremen-1 Antibody (R17-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Kremen-1 Antibody (R17-2) Specifications

Alternate Product Name: Kremen-1

Product Clone Name: R17-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a

Amino Acids:

Epitope Target: Kremen-1

Epitope Species: mouse

Product Reactivity/Detection: Kremen-1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG_2a in 1.0 ml of PBS with < 0.1% sodium azide and protein stabilizer

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for Kremen-1 Antibody (R17-2): N/A