PF 670462 (CAS 950912-80-8)

PF 670462 is a powerful and selective inhibitor that targets casein kinase, CK1ε, and CK1δ, while also exhibiting activity against 42 other kinases. Its multifaceted effects extend beyond kinase inhibition, as it can impede the nuclear translocation of Period circadian protein homolog 1 (PER1), leading to phase shifts in circadian rhythms. PF 670462 emerges as a highly potent and selective inhibitor of phosphatidylinositol-3-kinase (PI3K). The PI3K/AKT/mTOR signaling pathway, regulated by this enzyme, plays a pivotal role in controlling cell growth, survival, and metabolism. The inhibition of PI3K has shown anticancer effects in vitro. In the realm of PI3K inhibition, PF 670462 shines as a highly selective and potent agent. It operates by binding to the ATP-binding site of the enzyme, effectively blocking the activation of the PF 670462/AKT/mTOR signaling pathway. Through this blockade, cell proliferation, migration, and invasion are significantly curtailed. Notably, PF 670462 has demonstrated its efficacy in diminishing tumor growth and suppressing metastasis in animal models of cancer. Additionally, this compound exhibits anti-inflammatory and anti-angiogenic properties while displaying the potential to induce apoptosis in cancer cells.