KLKb8 Activators
KLKb8 Activators are a collection of chemical compounds that indirectly augment the functional activity of KLKb8 through the inhibition of other proteases, leading to increased substrate availability for KLKb8. Benzamidine, AEBSF, and Aprotinin are all inhibitors of serine proteases, and their action can result in a decreased competition for substrates that KLKb8 acts upon, thereby potentially enhancing its activity. Similarly, Gabexate, Nafamostat, and Camostat serve as broad-spectrum inhibitors of serine proteases, indirectly supporting KLKb8 by ensuring a greater substrate pool is available for its enzymatic action. Leupeptin, although a reversible inhibitor, also contributes to this process by inhibiting several serine proteases and thereby may lead to an indirect increase inKLKb8 activity. Additionally, E-64, while targeting cysteine proteases, could result in a surplus of substrates for KLKb8, further enhancing its proteolytic functions.
Pepstatin A and Phosphoramidon, targeting aspartic and metalloproteases respectively, create an environment that may favor the activity of KLKb8 by preventing the degradation of pertinent substrates. Amiloride, known for its role as a sodium channel blocker, also indirectly inhibits certain serine proteases, which could lead to an upsurge in available substrates for KLKb8, allowing it to perform its proteolytic functions more efficiently. Lastly, Tranexamic Acid, by inhibiting plasminogen activation, conserves proteins that might be substrates for KLKb8, potentially increasing the protease's overall activity. Collectively, these chemical compounds, through their targeted inhibition of various proteases, create a biochemical milieu that indirectly favors the enhancement of KLKb8's proteolytic activity without directly upregulating its expression or activation.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Benzamidine | 618-39-3 | sc-233933 | 10 g | $286.00 | 1 | |
Benzamidine is a reversible inhibitor of serine proteases, such as trypsin, which share similar substrate specificities with KLKb8. By inhibiting competitive serine proteases, benzamidine can lead to the increased substrate availability for KLKb8, thus potentially enhancing its functional activity. | ||||||
AEBSF hydrochloride | 30827-99-7 | sc-202041 sc-202041A sc-202041B sc-202041C sc-202041D sc-202041E | 50 mg 100 mg 5 g 10 g 25 g 100 g | $50.00 $120.00 $420.00 $834.00 $1836.00 $4896.00 | 33 | |
AEBSF (4-(2-Aminoethyl) benzenesulfonyl fluoride hydrochloride) is an irreversible serine protease inhibitor. When inhibiting other serine proteases in the same or intersecting pathways, AEBSF can indirectly increase the availability of substrates for KLKb8, thereby enhancing its activity. | ||||||
Aprotinin | 9087-70-1 | sc-3595 sc-3595A sc-3595B | 10 mg 100 mg 1 g | $110.00 $400.00 $1615.00 | 51 | |
Aprotinin, a protease inhibitor, targets several serine proteases within the cascade where KLKb8 is involved. By selectively inhibiting these proteases, aprotinin could theoretically lead to an accumulation of substrates that KLKb8 can then act upon, enhancing its activity. | ||||||
Gabexate mesylate | 56974-61-9 | sc-215066 | 5 mg | $100.00 | ||
Gabexate is a synthetic inhibitor of various serine proteases. By impeding the activity of proteases that compete with KLKb8 for substrates, gabexate indirectly increases the functional activity of KLKb8 by substrate channeling. | ||||||
Nafamostat mesylate | 82956-11-4 | sc-201307 sc-201307A | 10 mg 50 mg | $80.00 $300.00 | 4 | |
Nafamostat mesilate is a broad-spectrum serine protease inhibitor, potentially enhancing KLKb8 activity by reducing protease competition, allowing KLKb8 greater access to its specific substrates. | ||||||
Camostat mesylate | 59721-29-8 | sc-203867 sc-203867A sc-203867B sc-203867C sc-203867D sc-203867E | 10 mg 50 mg 500 mg 1 g 10 g 100 g | $42.00 $179.00 $306.00 $612.00 $2040.00 $4386.00 | 5 | |
Camostat mesilate is a serine protease inhibitor that may indirectly enhance the activity of KLKb8 by inhibiting other proteases in the cascade, thus increasing the availability of substrates for KLKb8. | ||||||
Leupeptin hemisulfate | 103476-89-7 | sc-295358 sc-295358A sc-295358D sc-295358E sc-295358B sc-295358C | 5 mg 25 mg 50 mg 100 mg 500 mg 10 mg | $72.00 $145.00 $265.00 $489.00 $1399.00 $99.00 | 19 | |
Leupeptin is a reversible inhibitor of several serine proteases as well as cysteine proteases. Its inhibition of competitive serine proteases may lead to enhanced activity of KLKb8 by increasing the pool of substrates that KLKb8 can act upon. | ||||||
E-64 | 66701-25-5 | sc-201276 sc-201276A sc-201276B | 5 mg 25 mg 250 mg | $275.00 $928.00 $1543.00 | 14 | |
E-64 is a potent inhibitor of cysteine proteases. While not directly enhancing KLKb8, E-64 can lead to increased substrate availability for KLKb8 by inhibiting proteases that cleave the same substrates. | ||||||
Phosphoramidon | 119942-99-3 | sc-201283 sc-201283A | 5 mg 25 mg | $195.00 $620.00 | 8 | |
Phosphoramidon is a metalloprotease inhibitor that may enhance KLKb8 activity by preventing the degradation of KLKb8 substrates by competitive metalloproteases, leaving more substrates for KLKb8. | ||||||
Amiloride • HCl | 2016-88-8 | sc-3578 sc-3578A | 25 mg 100 mg | $22.00 $56.00 | 6 | |
Amiloride, a sodium channel blocker, has been shown to inhibit some serine proteases indirectly. This could lead to a relative increase in KLKb8 activity due to reduced competition for substrate cleavage. | ||||||