Nafamostat mesylate CAS: 82956-11-4
MF: C19H17N5O2•2CH4O3S
MW: 539.6
A highly effective tryptase inhibitor.

Nafamostat mesylate (CAS 82956-11-4)

Nafamostat mesylate | CAS 82956-11-4 is rated 5.0 out of 5 by 1.
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Synonym: Nafamstat Mesilate; Futhan; 6-Amidino-2-naphthyl-4-guanidinobenzoate Dimethanesulfonate
Application: A highly effective tryptase inhibitor
CAS Number: 82956-11-4
Purity: ≥98%
Molecular Weight: 539.6
Molecular Formula: C19H17N5O22CH4O3S
* Refer to Certificate of Analysis for lot specific data (including water content).
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Nafamostat mesylate is a highly effective tryptase (Ki=95.3 pM) inhibitor. The compound has the ability to promote synthesis of interferon-γ, tumor necrosis factor-α, IL-12, and IL-18. Additionally, Nafamostat mesylate can induce production of intercellular adhesion molecules-1, B7.1, B7.2, CD40 and CD40 ligand in human blood mononuclear cells. Nafamostat mesylate is an anticoagulant and has been shown to decrease levels of plasma myeloperoxidase, and has also been used in ERCP pancreatitis studies. Nafamostat mesylate is an inhibitor of Factor X, Factor XII, granzyme A and KLK.


References

1. Inose, K., et al. 1997. Nephron. 75: 420-425. PMID: 9127328
2. Mori, S., et al. 2003. J. Pharmacol. Sci. 92: 420-423. PMID: 12939527
3. Katsuno, G., et al. 2005. J. Pharmacol. Sci. 98: 463-466. PMID: 16093612
4. Choi, C.W., et al. 2009. Gastrointest. Endosc. 69: e11-e18. PMID: 19327467

Physical State :
Solid
Solubility :
Soluble in DMSO (>10 mg/ml), water (25 mg/ml) Note: Phosphate-containing buffers may cause precipitation, and ethanol (<1 mg/mL) at 25° C.
Storage :
Store at room temperature
Melting Point :
260° C
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
nwg
RTECS :
DG2736000
PubChem CID :
5311180
Merck Index :
14: 6350
MDL Number :
MFCD00941430
SMILES :
CS(=O)(=O)O.CS(=O)(=O)O.C1=CC(=CC=C1C(=O)OC2=CC3=C(C=C2)C=C(C=C3)C(=N)N)N=C(N)N

Download SDS (MSDS)

Certificate of Analysis

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Nafamostat mesylate  Product Citations

See how others have used Nafamostat mesylate. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 27439606  Lee, PY.|Park, BC.|Chi, SW.|Bae, KH.|Kim, S.|Cho, S.|Kang, S.|Kim, JH.|Park, SG.| et al. 2016. BMB Rep. 49: 560-565.

PMID: # 26485396  Nimishakavi, S.|Raymond, WW.|Gruenert, DC.|Caughey, GH.| et al. 2015. PLoS ONE. 10: e0141169.

PMID: # 23447538  Raman, K.|Trivedi, NN.|Raymond, WW.|Ganesan, R.|Kirchhofer, D.|Verghese, GM.|Craik, CS.|Schneider, EL.|Nimishakavi, S.|Caughey, GH.| et al. 2013. J. Biol. Chem. 288: 10588-98.

Citations 1 to 3 of 3 total

What is the appearance of the compound?

Asked by: two2igm05
Thank you for your question. The compound, sc-201307, is provided as a white to light yellow powder. If you have any further questions or concerns, please feel free to contact our Technical Service department by calling 800-457-3801 option 2, emailing [email protected], or using the Live Chat function on our website.
Answered by: Tech Service 8
Date published: 2017-01-18
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Rated 5 out of 5 by from Katsuno et al Katsuno et al. (PubMed ID 16093612) found that nafamostat mesylate induced production of interleukin-12 and -18 in human peripheral blood mononuclear cells. -SCBT Publication Review
Date published: 2015-01-31
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