Molecular structure of AEBSF hydrochloride, CAS Number: 30827-99-7
AEBSF hydrochloride (CAS 30827-99-7)
See product citations (33)
Alternate Names:
AEBSF hydrochloride is also known as Pefabloc SC.
Application:
AEBSF hydrochloride is a broad spectrum, water soluble, irreversible serine protease inhibitor, TGF beta inhibitor, JNK activator, and p38 Map activator.
CAS Number:
30827-99-7
Purity:
≥97%
Molecular Weight:
239.69
Molecular Formula:
C8H10FNO2S•HCl
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
AEBSF hydrochloride is a broad spectrum, water soluble, irreversible serine protease inhibitor. AEBSF hydrochloride may act to inhibit the constitutive production of A beta in five different human cell lines, both neural and non-neural. AEBSF hydrochloride also inhibits activation of TGFβ (transforming growth factor beta), moderately inhibits CD26 (Dipeptidyl peptidase IV: DPP IV) and activates JNK and p38 MAP kinases. AEBSF hydrochloride is a b-secretase inhibitor that may act to inhibit beta amyloid peptide production and enhance APP (amyloid precursor protein) secretion in several cell lines at millimolar concentrations. AEBSF hydrochloride maintains stability at slightly acidic aqueous solutions and serves as a nontoxic alternative to PMSF (sc-3597) and DFP. AEBSF hydrochloride is also known as 4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride.
AEBSF hydrochloride (CAS 30827-99-7) References
- Proteolytic activation of latent TGF-beta precedes caspase-3 activation and enhances apoptotic death of lung epithelial cells. | Solovyan, VT. and Keski-Oja, J. 2006. J Cell Physiol. 207: 445-53. PMID: 16447253
- A single intrauterine injection of the serine protease inhibitor 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride reversibly inhibits embryo implantation in mice. | Sun, ZG., et al. 2007. Contraception. 76: 250-5. PMID: 17707725
- SLPI prevents cytokine release in mite protease-exposed conjunctival epithelial cells. | Seto, T., et al. 2009. Biochem Biophys Res Commun. 379: 681-5. PMID: 19103172
- A practical guide for the stabilization of acylghrelin in human blood collections. | Blatnik, M. and Soderstrom, CI. 2011. Clin Endocrinol (Oxf). 74: 325-31. PMID: 21050250
- Inhibition of proprotein convertase SKI-1 blocks transcription of key extracellular matrix genes regulating osteoblastic mineralization. | Gorski, JP., et al. 2011. J Biol Chem. 286: 1836-49. PMID: 21075843
- Serine protease inhibitor 4-(2-aminoethyl)benzenesulfonyl fluoride hydrochloride (AEBSF) inhibits the rat embryo implantation in vivo and interferes with cell adhesion in vitro. | Jiang, YH., et al. 2011. Contraception. 84: 642-8. PMID: 22078196
- The Serine Protease Inhibitor, 4-(2-aminoethyl) Benzene Sulfonyl Fluoride Hydrochloride, Reduces Allergic Inflammation in a House Dust Mite Allergic Rhinitis Mouse Model. | Kim, BY., et al. 2014. Allergy Asthma Immunol Res. 6: 558-66. PMID: 25374756
- The long form of pVHL is artifactually modified by serine protease inhibitor AEBSF. | Tarade, D., et al. 2020. Protein Sci. 29: 1843-1850. PMID: 32535973
- Biochemical Study of Fibrinolytic Protease from Euphausia superba Possessing Multifunctional Serine Protease Activity. | Qian, GY., et al. 2021. Protein Pept Lett. 28: 651-664. PMID: 33183186
- A Randomized Trial of the Effect of a GnRH Analogue Injection on Ghrelin Levels in Girls. | Rodanaki, M., et al. 2022. Horm Res Paediatr. 95: 442-451. PMID: 35896083
- Synthetic low molecular weight inhibitors of serum kallikrein. | Markwardt, F., et al. 1974. Biochem Pharmacol. 23: 2247-56. PMID: 4859519
- Irreversible enzyme inhibitors. 180. Irreversible inhibitors of the C'la component of complement derived from m-(phenoxypropoxy)benzamidine and phenoxyacetamide. | Baker, BR. and Cory, M. 1971. J Med Chem. 14: 119-25. PMID: 5544395
- Studies on the inhibition of human thrombin: effects of plasma and plasma constituents. | Lawson, WB., et al. 1982. Folia Haematol Int Mag Klin Morphol Blutforsch. 109: 52-60. PMID: 6177608
- Dipeptidyl peptidase IV from porcine seminal plasma: purification, characterization, and N-terminal amino acid sequence. | Ohkubo, I., et al. 1994. J Biochem. 116: 1182-6. PMID: 7896751
- Inhibition of amyloid beta-protein production in neural cells by the serine protease inhibitor AEBSF. | Citron, M., et al. 1996. Neuron. 17: 171-9. PMID: 8755488
Inhibitor of:
α2ML1, 5430419D17Rik, A430107O13Rik, ASTL, ATF-6, C1q-A, CLPSL1, Corin, CPA1, CPA2, CPA5, CPAMD8, CPD, Desc4, EG436523, ENSMUSG00000071517, Enterokinase, ERp27, FAM162B, FAM190A, Gm46, gp91phox, Granzyme, granzyme A, granzyme C, granzyme E, granzyme F, granzyme G, granzyme H, granzyme M, granzyme N, group V PLA2, HKIB9, HtrA4, Kex2, Klk1b4, Klk26, KLKb2, Klkb21, Klkb22, KLKBL4, Lysozyme C, Marapsin 2, Mast Cell Protease, Mast Cell Protease 5, Mast Cell Protease 8, Matriptase, Matriptase-2, MC-CPA, Mesotrypsinogen, Mox1, MUP2, MUP3, murinoglobulin 2, neuroserpin, Neurotrypsin, NIPBL, NOXA1, NOXRED1, OTTMUSG00000013284, OTTMUSG00000014862, OTTMUSG00000015173, OTTMUSG00000015220, OTTMUSG00000015279, OTTMUSG00000015337, OTTMUSG00000015417, OTTMUSG00000015643, OTTMUSG00000015752, OTTMUSG00000016293, OVCA2, p22-phox, p40-phox, PAI-2, PCSK1N, Polyserase-1, PRB1-3, PRB2, PRB3, prochymosin, Pronase, Prostasin, PRSS16, Prss28, Prss29, Prss32, PRSS33, Prss34, PRSS35, PRSS37, Prss39, PRSS44, Prss47, PRSS50, PRSS51, PRSSL1, PTAG, PTPλ, RHBDD2, RHBDL2, Rhomboid, SEC11A, Sel-1L3, Semenogelin-2, SerpinA11, SerpinA1b, SerpinA1e, SerpinA3j, SerpinA3n, SerpinB11, SerpinB1b, Serpinb3c, Serpinb3d, SerpinB6B, SerpinB6C, Serpinb6d, SerpinB6e, SerpinB8, SerpinB9g, SERPINE3, SERTM1, SIL1, SKI-1, Spi10, SPINK10, SPINK14, SPINK2, SPINK3, SPINK6, SPINK7, SPUVE, TATI, TESP3, Testisin, TGF beta, TLCK, TMPRSS11A, TMPRSS11B, TMPRSS11E, TMPRSS11F, TMPRSS12, TMPRSS13, TMPRSS3, TMPRSS4, TMPRSS5, TPCK, TRIM50, Trypsin X3, Trypsin-1, Trypsin-5, Tryptase γ, TSP50, uPA, WFDC17, and ZFP30.Activator of:
1700074P13Rik, APMSF, Chromozym TRY, CRISP-8, GEFT, Gm4788, HAI-2, HSBP1L1, JNK, KLK15, Klk1b4, Klk26, KLK5, KLK9, KLKb8, LOC646960, p38, PN-1, Prss28, Prss29, PRSS35, Prss39, Prss47, SERHL, SerpinA3i, Serpinb3b, stefin A1L1, Tesp2, TESSP-1, TMPRSS11B, TMPRSS11E2, TMPRSS11F, TMPRSS3, TMPRSS7, TMPRSSs8, TPSB1, and Trypsin-10.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
AEBSF hydrochloride, 50 mg | sc-202041 | 50 mg | $65.00 | |||
AEBSF hydrochloride, 100 mg | sc-202041A | 100 mg | $122.00 | |||
AEBSF hydrochloride, 5 g | sc-202041B | 5 g | $428.00 | |||
AEBSF hydrochloride, 10 g | sc-202041C | 10 g | $851.00 | |||
AEBSF hydrochloride, 25 g | sc-202041D | 25 g | $1873.00 | |||
AEBSF hydrochloride, 100 g | sc-202041E | 100 g | $4994.00 |