You may not log in without verifying your email address.
Please check your email (including your spam email) for the Welcome message that was sent.
Camostat mesylate, a protease inhibitor, has been found to cause significant increase in the bicarbonate concentration, secretory rate, and output of pancreatic juice of dogs. Furthermore it was found that this water induction and bicarbonate secretion increase was achieved via direct regulation of ductular cells of the dog pancreas. Other studies have shown Camostat mesylate to suppress spinal Fos expression in the rat, which is a marker for neuronal activation. In addition it was shown that this compound may prevent or depress pancreatitis-induced referred allodynia/hyperalgesia in rat models. Camostat mesylate has also demonstrated the ability to prevent Trypsin attack of microspheres, which causes the degradation product N-benzoyl-dl-arginine. Camostat mesylate is an inhibitor of KLK, plasminogen, Prothrombin and Trypsin.
1. Horiuchi, A., et al. 1990. J. Pharmacol. Exp. Ther. 252: 320-326. PMID: 1688943
2. Uchida, T., et al. 2001. J. Pharm. Pharmacol. 53: 255-261. PMID: 11273024
3. Ishikura, H., et al. 2007. Life Sci. 80: 1999-2004. PMID: 17433371
4. Togami, K., et al. 2009. Rinsho Ketsueki. 50: 1700-1705. PMID: 20068277
See how others have used Camostat mesylate. Click on the entry to view the PubMed entry .
PMID: # 26485396 Nimishakavi, S.|Raymond, WW.|Gruenert, DC.|Caughey, GH.| et al. 2015. PLoS ONE. 10: e0141169.
PMID: # 31550238 J. Clin. Invest.
PMID: # 22406536 J. Clin. Invest. 122: 1519-28.
Santa Cruz Biotechnology, Inc. is a world leader in the development of products for the biomedical research market. Call us Toll Free at 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved. "Santa Cruz Biotechnology", and the Santa Cruz Biotechnology, Inc. logo, "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", the San Juan Ranch logo, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", and "EZ Touch" are registered trademarks of Santa Cruz Biotechnology, Inc.
All trademarks are the property of their respective owners.