Camostat mesylate CAS: 59721-29-8
MF: C20H22N4O5•CH3SO3H
MW: 494.52
A protease and Trypsin inhibitor.

Camostat mesylate (CAS 59721-29-8)

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Synonym: camostat mesilate
Application: A protease and Trypsin inhibitor
CAS Number: 59721-29-8
Purity: >98%
Molecular Weight: 494.52
Molecular Formula: C20H22N4O5•CH3SO3H
* Refer to Certificate of Analysis for lot specific data (including water content).
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Camostat mesylate, a protease inhibitor, has been found to cause significant increase in the bicarbonate concentration, secretory rate, and output of pancreatic juice of dogs. Furthermore it was found that this water induction and bicarbonate secretion increase was achieved via direct regulation of ductular cells of the dog pancreas. Other studies have shown Camostat mesylate to suppress spinal Fos expression in the rat, which is a marker for neuronal activation. In addition it was shown that this compound may prevent or depress pancreatitis-induced referred allodynia/hyperalgesia in rat models. Camostat mesylate has also demonstrated the ability to prevent Trypsin attack of microspheres, which causes the degradation product N-benzoyl-dl-arginine. Camostat mesylate is an inhibitor of KLK, plasminogen, Prothrombin and Trypsin.


References

1. Horiuchi, A., et al. 1990. J. Pharmacol. Exp. Ther. 252: 320-326. PMID: 1688943
2. Uchida, T., et al. 2001. J. Pharm. Pharmacol. 53: 255-261. PMID: 11273024
3. Ishikura, H., et al. 2007. Life Sci. 80: 1999-2004. PMID: 17433371
4. Togami, K., et al. 2009. Rinsho Ketsueki. 50: 1700-1705. PMID: 20068277

Physical State :
Solid
Solubility :
Soluble in water (100 mM), DMSO (100 mM), and ethanol (<1 mg/ml).
Storage :
Desiccate at room temperature
Refractive Index :
n20D 1.60 (Predicted)
IC50 :
Trypsin-1: IC50 = 50.6 nM (human); Human neutrophil elastase: IC50 = 0.2 µM; Matriptase: IC50 = 0.5 µM; KLK1: IC50 = 1.48 µM (human); Plasminogen: IC50 = 2.62 µM (rat)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
RTECS :
CY1571620
PubChem CID :
5284360
MDL Number :
MFCD00941410
SMILES :
CN(C)C(=O)COC(=O)CC1=CC=C(C=C1)OC(=O)C2=CC=C(C=C2)N=C(N)N.CS(=O)(=O)O

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Certificate of Analysis

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Camostat mesylate  Product Citations

See how others have used Camostat mesylate. Click on the entry to view the PubMed entry .

Citations 1 to 3 of 3 total

PMID: # 26485396  Nimishakavi, S.|Raymond, WW.|Gruenert, DC.|Caughey, GH.| et al. 2015. PLoS ONE. 10: e0141169.

PMID: # 31550238  J. Clin. Invest.

PMID: # 22406536  J. Clin. Invest. 122: 1519-28.

Citations 1 to 3 of 3 total
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