Date published: 2026-4-1

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KLK7 Inhibitors

KLK7 inhibitors as a chemical class consist of molecules that can interact with the active site or modulate the function of kallikrein-related peptidase 7. Inhibitors typically target the serine protease activity of KLK7, either directly by binding to its active site or indirectly through modulating associated proteolytic pathways. Molecules like AEBSF, leupeptin, and aprotinin are designed to interact with the active sites of serine proteases, preventing them from engaging with their specific substrates. Such interactions lead to a decrease in protease activity, which in the context of KLK7, translates to reduced proteolysis. The inhibition of KLK7 can also be achieved indirectly by compounds that modulate related pathways. Metalloprotease inhibitors like phosphoramidon, or broad-spectrum serine protease inhibitors such as gabexate mesilate and camostat mesilate, do not inhibit KLK7 directly but may affect its activity through systemic alterations in protease networks. Matrix metalloproteinase inhibitors like marimastat and ilomastat are not selective for KLK7 but could indirectly impact its function through changes in the extracellular matrix, which can influence the environment where KLK7 is active. Chymostatin, targeting chymotrypsin-like proteases, also has the potential to affect the activity of related proteases, thereby influencing the biological processes KLK7 is involved in.

Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

AEBSF hydrochloride

30827-99-7sc-202041
sc-202041A
sc-202041B
sc-202041C
sc-202041D
sc-202041E
50 mg
100 mg
5 g
10 g
25 g
100 g
$65.00
$122.00
$428.00
$851.00
$1873.00
$4994.00
33
(1)

AEBSF is a serine protease inhibitor that irreversibly binds to the active site of serine residues in proteases, thereby preventing the cleavage of peptide bonds by these enzymes. It can affect KLK7's activity by inhibiting its proteolytic function.

Leupeptin hemisulfate

103476-89-7sc-295358
sc-295358A
sc-295358D
sc-295358E
sc-295358B
sc-295358C
5 mg
25 mg
50 mg
100 mg
500 mg
10 mg
$73.00
$148.00
$316.00
$499.00
$1427.00
$101.00
19
(3)

Leupeptin is a reversible inhibitor of serine and cysteine proteases. It forms a stable, reversible complex with these proteases, which includes potential interaction with KLK7, thereby affecting its protease activity.

E-64

66701-25-5sc-201276
sc-201276A
sc-201276B
5 mg
25 mg
250 mg
$281.00
$947.00
$1574.00
14
(0)

E-64 is an irreversible inhibitor that targets cysteine proteases by binding covalently to the active site. While it is specific for cysteine proteases, its effect on the broader protease network can influence KLK7 function indirectly.

Phosphoramidon

119942-99-3sc-201283
sc-201283A
5 mg
25 mg
$199.00
$632.00
8
(1)

This is a metalloprotease inhibitor that chelates zinc ions required for the activity of metalloproteases. While it does not inhibit KLK7 directly, it may influence KLK7 activity by modulating related proteolytic pathways.

Aprotinin

9087-70-1sc-3595
sc-3595A
sc-3595B
10 mg
100 mg
1 g
$112.00
$408.00
$3000.00
51
(2)

Aprotinin is a polypeptide that inhibits several serine proteases, including kallikreins. By inhibiting related proteases, aprotinin can modify the proteolytic environment and indirectly influence KLK7 activity.

Gabexate mesylate

56974-61-9sc-215066
5 mg
$100.00
(0)

This is a synthetic serine protease inhibitor that can modulate the activity of multiple enzymes in the coagulation cascade. Through its broad-spectrum inhibition, it may have an effect on KLK7's role in processes related to coagulation and inflammation.

Camostat mesylate

59721-29-8sc-203867
sc-203867A
sc-203867B
sc-203867C
sc-203867D
sc-203867E
10 mg
50 mg
500 mg
1 g
10 g
100 g
$43.00
$183.00
$312.00
$624.00
$2081.00
$4474.00
5
(0)

Camostat is a serine protease inhibitor with actions on various proteases involved in the fibrinolytic system. It may affect KLK7 by altering the balance of serine proteases involved in skin desquamation and inflammation.

Nafamostat mesylate

82956-11-4sc-201307
sc-201307A
10 mg
50 mg
$82.00
$306.00
4
(1)

Nafamostat is a broad-spectrum serine protease inhibitor that can influence a range of proteases. By modifying serine protease activity, it could affect KLK7's function indirectly through systemic protease inhibition.

Marimastat

154039-60-8sc-202223
sc-202223A
sc-202223B
sc-202223C
sc-202223E
5 mg
10 mg
25 mg
50 mg
400 mg
$168.00
$218.00
$404.00
$629.00
$4900.00
19
(1)

Although primarily a matrix metalloproteinase inhibitor, marimastat's inhibition of protease activity can influence the extracellular matrix and cellular processes that KLK7 might be involved in, thereby affecting its function.

GM 6001

142880-36-2sc-203979
sc-203979A
1 mg
5 mg
$77.00
$270.00
55
(1)

Also known as GM6001, ilomastat is a matrix metalloproteinase inhibitor that could indirectly influence KLK7 activity by altering matrix turnover and related signaling pathways that KLK7 could interact with.