KLHL26 Activators
KLHL26 operate through a series of well-defined molecular pathways that often converge on the modulation of intracellular cyclic AMP (cAMP) levels and subsequent activation of protein kinase A (PKA). Forskolin, by directly stimulating adenylyl cyclase, swiftly increases cAMP within the cell, thereby facilitating the activation of PKA. Isoproterenol, a beta-adrenergic agonist, also triggers this pathway albeit through initial engagement with beta-adrenergic receptors. Similar mechanisms are employed by other compounds like Terbutaline, Salbutamol, and Epinephrine, which likewise interact with beta-adrenergic receptors leading to adenylyl cyclase activation. Prostaglandin E2 (PGE2) and Adenosine, through their respective G protein-coupled receptors, equally contribute to the rise in cAMP and subsequent PKA activation. Dopamine and Histamine, by binding to their specific Gs protein-coupled receptors, also promote adenylyl cyclase activity and cAMP production. In the case of Glucagon, its receptor-mediated activation of adenylyl cyclase follows a similar trajectory to increase cAMP levels. PKA, once activated by these elevated cAMP levels, then acts to phosphorylate KLHL26, which serves as a critical step in its functional activation.
IBMX, Rolipram, and Terbutaline inhibit the phosphodiesterases responsible for cAMP breakdown. IBMX is a broad-spectrum phosphodiesterase inhibitor, leading to a global increase in cAMP within the cell, whereas Rolipram selectively inhibits phosphodiesterase 4, resulting in a more targeted increase in cAMP. This build-up of cAMP facilitates sustained activation of PKA over a longer duration. The consistent theme across all these chemical activators is the elevation of intracellular cAMP and the subsequent activation of PKA, which in turn phosphorylates KLHL26. This phosphorylation event is a pivotal step in the activation of KLHL26, enabling it to perform its cellular functions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin directly activates adenylyl cyclase, increasing cyclic AMP (cAMP) levels in cells. Elevated cAMP activates protein kinase A (PKA), which can phosphorylate KLHL26, leading to its functional activation. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $27.00 $37.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that stimulates adenylyl cyclase via G protein-coupled receptor signaling, leading to increased cAMP and subsequent activation of PKA. PKA then potentially phosphorylates and functionally activates KLHL26. | ||||||
PGE2 | 363-24-6 | sc-201225 sc-201225C sc-201225A sc-201225B | 1 mg 5 mg 10 mg 50 mg | $56.00 $156.00 $270.00 $665.00 | 37 | |
Prostaglandin E2 (PGE2) engages G protein-coupled receptors that signal through adenylyl cyclase to increase cAMP and activate PKA. PKA can then phosphorylate and activate KLHL26. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $159.00 $315.00 $598.00 | 34 | |
3-Isobutyl-1-methylxanthine (IBMX) is a non-selective inhibitor of phosphodiesterases, enzymes that break down cAMP. By inhibiting phosphodiesterases, IBMX raises intracellular cAMP levels, which activates PKA, and this in turn could lead to the phosphorylation and activation of KLHL26. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $40.00 $102.00 $197.00 $1739.00 $16325.00 | ||
Epinephrine binds to and activates beta-adrenergic receptors, causing increased production of cAMP via adenylyl cyclase activation. The rise in cAMP activates PKA, which may then activate KLHL26 through phosphorylation. | ||||||
Dopamine | 51-61-6 | sc-507336 | 1 g | $290.00 | ||
Dopamine can bind to dopamine D1-like receptors which couple to Gs proteins that activate adenylyl cyclase, increasing cAMP and activating PKA. PKA could then phosphorylate and activate KLHL26. | ||||||
Histamine, free base | 51-45-6 | sc-204000 sc-204000A sc-204000B | 1 g 5 g 25 g | $92.00 $277.00 $969.00 | 7 | |
Histamine can bind to H2 receptors, which are Gs protein-coupled receptors that activate adenylyl cyclase, increasing cAMP and subsequently activating PKA. PKA activation may lead to phosphorylation and functional activation of KLHL26. | ||||||
Adenosine | 58-61-7 | sc-291838 sc-291838A sc-291838B sc-291838C sc-291838D sc-291838E sc-291838F | 1 g 5 g 100 g 250 g 1 kg 5 kg 10 kg | $33.00 $47.00 $294.00 $561.00 $1020.00 $2550.00 $4590.00 | 1 | |
Adenosine engages A2A receptors, which are coupled to Gs proteins that activate adenylyl cyclase. The resulting increase in cAMP activates PKA, which may phosphorylate and activate KLHL26. | ||||||
Terbutaline Hemisulfate | 23031-32-5 | sc-204911 sc-204911A | 1 g 5 g | $90.00 $371.00 | 2 | |
Terbutaline is a beta2-adrenergic agonist that causes adenylyl cyclase activation via G protein-coupled receptor signaling. The increase in cAMP leads to PKA activation, which could phosphorylate and activate KLHL26. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $75.00 $212.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4, which breaks down cAMP. Its inhibition leads to increased cAMP levels, thereby activating PKA, which may phosphorylate and activate KLHL26. | ||||||