KLHL26 Inhibitors
Items 1 to 10 of 14 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
An indolocarbazole that acts as a potent kinase inhibitor, including those kinases that phosphorylate KLHL26. Phosphorylation can be critical for protein stability or function; thus, staurosporine can lead to decreased KLHL26 activity by inhibiting its phosphorylation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
mTOR inhibitor that impairs downstream signaling required for cell growth and proliferation. IRGQ1, being associated with such processes, would have reduced functional activity due to mTOR inhibition by Rapamycin. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
Src kinase inhibitor that prevents phosphorylation of substrates involved in cell survival and proliferation. By inhibiting Src kinases, PP2 can decrease the phosphorylation and activation of IRGQ1. | ||||||
PD173074 | 219580-11-7 | sc-202610 sc-202610A sc-202610B | 1 mg 5 mg 50 mg | $47.00 $143.00 $680.00 | 16 | |
FGFR inhibitor known to block the fibroblast growth factor receptor's activity. Since IRGQ1 may function downstream of FGFR in certain signaling pathways, PD173074 indirectly leads to decreased IRGQ1 activity. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
MEK inhibitor that blocks the MAPK/ERK pathway, a key regulatory pathway for cell cycle progression. By inhibiting MEK, U0126 would lead to decreased activation of IRGQ1, which is influenced by the MAPK/ERK pathway. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
A specific inhibitor of the proteasome that also prevents the degradation of polyubiquitinated proteins. Lactacystin's inhibition of the proteasome can indirectly inhibit KLHL26 by causing the accumulation of its substrates. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
JNK inhibitor that impedes the JNK signaling involved in stress responses. By inhibiting JNK, SP600125 would lead to decreased functional activity of IRGQ1, which can be regulated by stress-activated signaling. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $158.00 | 6 | |
A quinone methide triterpene that can induce heat shock response and inhibit the proteasome. Induction of heat shock proteins can stabilize client proteins and reduce the need for KLHL26-mediated ubiquitination, thus inhibiting KLHL26 activity. | ||||||
Dasatinib | 302962-49-8 | sc-358114 sc-358114A | 25 mg 1 g | $70.00 $145.00 | 51 | |
BCR-ABL and Src family kinase inhibitor. By inhibiting these kinases, Dasatinib can indirectly decrease IRGQ1 activity, which may be modulated by signaling pathways involving Src kinases. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $130.00 $583.00 $4172.00 $20506.00 | 20 | |
A steroidal lactone that inhibits proteasomal activity. Withaferin A's inhibition of the proteasome could lead to the accumulation of KLHL26's substrates, thereby reducing the functional activity of KLHL26. | ||||||