Staurosporine CAS: 62996-74-1
MF: C28H26N4O3
MW: 466.53

Staurosporine (CAS 62996-74-1)

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Alternate Names: Staurosporine is also known as Staurosporin and Antibiotic AM-2282.
Application Staurosporine is an antifungal inhibitor of many different kinases via interaction with the ATP binding site
CAS 등록번호: 62996-74-1
순도: >99%
분자량: 466.53
분자식: C28H26N4O3
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
* 참조분석증명서대량의 측정 데이터(함수량포함).
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Staurosporine, also referred to as Antibiotic AM-2282, is a microbial alkaloid with antifungal activity. Staurosporine has been shown to inhibit a variety of kinases via interaction with the ATP binding site. Staurosporine induces association of purified PKC with inside-out vesicles from erythrocyte membranes and augments PMA-induced ornithine decarboxylase. Staurosporine also activates a bcl-2-regulated apoptosis pathway. Kinases inhibited by Staurosporine include PKA (Ki=7.0 nM), PKG (Ki=8.5 nM), MYLK (MLCK, Ki=1.3 nM), PKC (Ki=0.7 nM), CaMK (IC50=20 nM), CAMKII (Ki=20nM), tyrosine kinases (IC50=70 nM) and phosphorylase kinase (IC50=0.5 nM). Further, there is evidence that Staurosporine inhibits c-Src, Cdc2, Cdk2, Cdk4, Cdk5, cGKI, cyclin A, cyclin B, cyclin D, Fgr, GSK-3 beta, Lyn, p35, Pim-3, PKC alpha, Syk and Topo II.


References

1. Tamaoki, T., et al. 1986. Biochem. Biophys. Res. Commun. 135: 397-402. PMID: 3457562
2. Wolf, M., et al. 1988. Biochem. Biophys. Res. Commun. 154: 1273-1279. PMID: 3408497
3. Matsumoto, H., et al. 1989. Biochem. Biophys. Res. Commun. 158: 105-109. PMID: 2912441
4. Fallon, R.J. 1990. Biochem. Biophys. Res. Commun. 170: 1191-1196. PMID: 2167672
5. Elliott, L.H., et al. 1990. Biochem. Biophys. Res. Commun. 171: 148-154. PMID: 2393389
6. Badwey, J.A., et al. 1991. Biochem. Biophys. Res. Commun. 178: 423-429. PMID: 1859401
7. Yanagihara, N., et al. 1991. J. Neurochem. 56: 294-298. PMID: 1846174

Physical State :
Solid
에서 유래된 :
Streptomyces sp. MST-AS5345
용해도 :
Soluble in DMSO (25 mg/ml), DMF (25 mg/ml), ethyl acetate, hot acetone, and ethanol. Slightly soluble in chloroform, and methanol, Insoluble in water.
저장 :
Store at -20° C
녹는점 :
240-243° C
비등점 :
~677.5° C at 760 mmHg (Predicted)
밀도 :
~1.6 g/cm3 (Predicted)
굴절률 :
n20D 1.81
IC50 :
Chk1: IC50 = <0.5 nM (human); Akt3: IC50 = 0.64 nM (human); phosphorylase kinase: IC50 = 0.5 nM; Tyrosine-protein kinase SRC: IC50 = 1.0 nM (human); AMPK: IC50 = <1.0 nM (human)
Ki 데이타 :
Polo-Like Kinase 4: Ki= 2.6 nM (human); Tyrosine-protein kinase ITK: Ki= 2.2 nM (human); MLCK: Ki= 1.3 nM; PKC: Ki= 0.7 nM; CDK1: Ki= 1.0 nM (human)
pK Values :
pKb: 8.97
연구용으로만 사용가능합니다. 진단이나 치료용으로 사용불가합니다.
RTECS :
KD5084000
PubChem CID :
44259
Merck Index :
14: 8802
MDL Number :
MFCD00077402
SMILES :
C[[email protected]@]12[[email protected]@H]([[email protected]@H](C[[email protected]@H](O1)N3C4=CC=CC=C4C5=C6C(=C7C8=CC=CC=C8N2C7=C53)CNC6=O)NC)OC

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Staurosporine (CAS 62996-74-1)  논문정보

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Citations 1 to 10 of {3} total

PMID: # 30760300  Yang, WC. et al. 2019. J Neuroinflammation. 16: 36.

PMID: # 31325684  Ribeiro, V. et al. 2019. Phytomedicine. 63: 153017.

PMID: # 30967464  Giebel, AM.|Hu, S.|Rajaram, K.|Finethy, R.|Toh, E.|Brothwell, JA.|Morrison, SG.|Suchland, RJ.|Stein, BD.|Coers, J.|Morrison, RP.|Nelson, DE.| et al. 2019. MBio. 10:

PMID: # 30485805  Chauhan, D. et al. 2018. Cell Rep. 25: 2354-2368.e5.

PMID: # 29395868  Eberl, M. et al. 2018. Cancer Cell. 33: 229-243.e4.

PMID: # 30139286  Chen, X.|Zha, GF.|Wang, JQ.|Liu, XH.| et al. 2018. J Enzyme Inhib Med Chem. 33: 1266-1270.

PMID: # 30006243  Luczak, MW.|Zhitkovich, A.| et al. 2018. Toxicol. Appl. Pharmacol. 355: 238-246.

PMID: # 28837145  Cheng, X.|Shi, JB.|Liu, H.|Chen, LZ.|Wang, Y.|Tang, WJ.|Liu, XH.| et al. 2017. Cell Death Dis. 8: e3016.

PMID: # 28304352  2017. Int J Mol Sci. 18:

PMID: # 28234980  Faria, M. et al. 2017. PLoS ONE. 12: e0172689.

Citations 1 to 10 of {3} total
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