KLHL36 Antibody (F-7): sc-514015

KLHL36 Antibody (F-7) is a mouse monoclonal IgG1 antibody that detects KLHL36 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-KLHL36 antibody (F-7) recognizes a 616 amino acid protein characterized by six Kelch repeats, one BTB/POZ domain, and one BTB/Kelch associated (BACK) domain, which are crucial for protein ubiquitination. KLHL36 (F-7) antibody identifies a protein that functions as a substrate-specific adapter within an E3 ubiquitin-protein ligase complex, facilitating ubiquitin transfer from E2 ubiquitin-conjugating enzymes to target proteins destined for degradation. KLHL36 interacts with CUL-3, a key member of the cullin family essential for selective targeting of proteins for ubiquitin-mediated proteolysis, influencing cellular processes such as cell cycle regulation and signal transduction. Alternative splicing of KLHL36 results in two isoforms, which may have distinct functional roles in cellular contexts. KLHL36 monoclonal antibody (F-7) effectively detects this target across multiple species, making KLHL36 (F-7) antibody valuable for studying ubiquitination pathways and their implications in health and disease.

The preferred KLHL36 antibody is KLHL36 Antibody (E-2): sc-390052.