KLHL36 Antibody (E-2): sc-390052
- KLHL36 Antibody (E-2) is a mouse monoclonal IgG1 κ KLHL36 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 3-29 near the N-terminus of KLHL36 of human origin
- KLHL36 Antibody (E-2) is recommended for detection of KLHL36 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA; also reactive with additional species, including and equine, canine and bovine
- Anti-KLHL36 Antibody (E-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for KLHL36 Antibody (E-2) for WB and IHC(P) applications. These reagents are now offered in bundles with KLHL36 Antibody (E-2) (see ordering information below).
KLHL36 Antibody (E-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects KLHL36 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). KLHL36 (E-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KLHL36 protein, consisting of 616 amino acids, features six Kelch repeats, a BTB/POZ domain, and a BTB/Kelch associated (BACK) domain, which are crucial for function in protein ubiquitination. KLHL36 plays a significant role as a substrate-specific adapter in an E3 ubiquitin-protein ligase complex, facilitating transfer of ubiquitin from E2 ubiquitin-conjugating enzymes to target proteins destined for degradation. KLHL36 interacts with CUL-3, a member of the cullin family essential for selective targeting of proteins for ubiquitin-mediated proteolysis. Due to alternative splicing events, two isoforms of KLHL36 are expressed, contributing to functional diversity in different biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
KLHL36 Antibody (E-2) References:
- One ring to rule a superfamily of E3 ubiquitin ligases. | Tyers, M. and Willems, AR. 1999. Science. 284: 601, 603-4. PMID: 10328744
- Cullin-3 targets cyclin E for ubiquitination and controls S phase in mammalian cells. | Singer, JD., et al. 1999. Genes Dev. 13: 2375-87. PMID: 10500095
- Identification of the von Hippel-lindau tumor-suppressor protein as part of an active E3 ubiquitin ligase complex. | Iwai, K., et al. 1999. Proc Natl Acad Sci U S A. 96: 12436-41. PMID: 10535940
- Giant axonal neuropathy. | Yang, Y., et al. 2007. Cell Mol Life Sci. 64: 601-9. PMID: 17256086
- Genotype-phenotype analysis in patients with giant axonal neuropathy (GAN). | Koop, O., et al. 2007. Neuromuscul Disord. 17: 624-30. PMID: 17587580
- The Nodosome: Nod1 and Nod2 control bacterial infections and inflammation. | Tattoli, I., et al. 2007. Semin Immunopathol. 29: 289-301. PMID: 17690884
- Identification, evolution, and association study of a novel promoter and first exon of the human NOD2 (CARD15) gene. | King, K., et al. 2007. Genomics. 90: 493-501. PMID: 17719742
- High frequency of mosaic CREBBP deletions in Rubinstein-Taybi syndrome patients and mapping of somatic and germ-line breakpoints. | Gervasini, C., et al. 2007. Genomics. 90: 567-73. PMID: 17855048
- Nod-like receptors in innate immunity and inflammatory diseases. | Carneiro, LA., et al. 2007. Ann Med. 39: 581-93. PMID: 18038361
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KLHL36 Antibody (E-2) | sc-390052 | 200 µg/ml | $322.00 | |||
KLHL36 Antibody (E-2): m-IgG Fc BP-HRP Bundle | sc-530053 | 200 µg Ab; 10 µg BP | $361.00 | |||
KLHL36 Antibody (E-2): m-IgGκ BP-HRP Bundle | sc-523387 | 200 µg Ab, 40 µg BP | $361.00 | |||
KLHL36 Antibody (E-2): m-IgG1 BP-HRP Bundle | sc-543841 | 200 µg Ab; 20 µg BP | $361.00 | |||
KLHL36 Antibody (E-2) AC | sc-390052 AC | 500 µg/ml, 25% agarose | $424.00 | |||
KLHL36 Antibody (E-2) HRP | sc-390052 HRP | 200 µg/ml | $322.00 | |||
KLHL36 Antibody (E-2) FITC | sc-390052 FITC | 200 µg/ml | $336.00 | |||
KLHL36 Antibody (E-2) PE | sc-390052 PE | 200 µg/ml | $349.00 | |||
KLHL36 Antibody (E-2) Alexa Fluor® 488 | sc-390052 AF488 | 200 µg/ml | $364.00 | |||
KLHL36 Antibody (E-2) Alexa Fluor® 546 | sc-390052 AF546 | 200 µg/ml | $364.00 | |||
KLHL36 Antibody (E-2) Alexa Fluor® 594 | sc-390052 AF594 | 200 µg/ml | $364.00 | |||
KLHL36 Antibody (E-2) Alexa Fluor® 647 | sc-390052 AF647 | 200 µg/ml | $364.00 | |||
KLHL36 Antibody (E-2) Alexa Fluor® 680 | sc-390052 AF680 | 200 µg/ml | $364.00 | |||
KLHL36 Antibody (E-2) Alexa Fluor® 790 | sc-390052 AF790 | 200 µg/ml | $364.00 | |||
KLHL36 (E-2) Neutralizing Peptide | sc-390052 P | 100 µg/0.5 ml | $69.00 |