KLHDC8B Activators
KLHDC8B activators are a class of chemicals that modulate the activity of the protein KLHDC8B. This protein is a member of the Kelch domain-containing family, which is known for a diversity of cellular functions, often related to interactions with actin and involvement in cytoskeletal organization. The specific biological role of KLHDC8B is not exhaustively understood, but it is presumed to participate in cellular processes that require fine-tuned regulation of protein interactions. Activators of KLHDC8B aim to enhance the protein's functional activity, which could involve promoting protein-protein interactions, facilitating the proper folding of the protein, or stabilizing the protein structure in its active state. These chemical activators would typically be small molecules capable of penetrating cellular membranes to interact with intracellular KLHDC8B, and they would bind to specific sites on the protein to exert their modulatory effects.
The discovery and optimization of KLHDC8B activators are grounded in a comprehensive understanding of the protein's three-dimensional structure and dynamics. The design of these activators involves a targeted approach, where computational models can predict the interaction between the small molecule and the protein, guiding the synthesis of compounds with the desired activity profile. Subsequent in vitro and in vivo assays are essential to validate the efficacy of these compounds, ensuring that they indeed enhance the activity of KLHDC8B. The specificity of KLHDC8B activators is also critical, as off-target interactions can lead to unintended cellular consequences.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A polyphenol found in green tea, known to modulate a variety of cellular signaling pathways, including those related to cellular stress responses, which could increase the expression of proteins like KLHDC8B as part of a cellular adaptation mechanism. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
An activator of adenylate cyclase which increases cAMP levels, potentially modulating protein kinase A activity and affecting transcription factors that regulate genes like KLHDC8B. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A bioactive compound in turmeric, it modulates several signal transduction pathways and may upregulate genes involved in cellular stress responses, potentially including KLHDC8B. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
A phytoalexin that activates SIRT1 and can modulate stress response pathways, which might lead to the upregulation of stress response proteins, potentially including KLHDC8B. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
An isothiocyanate that activates NRF2, leading to the expression of antioxidant response element (ARE)-driven genes, which could include KLHDC8B if it is related to cellular antioxidant defenses. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Through inhibition of GSK-3β, it may alter Wnt signaling and potentially influence the expression of genes downstream of this pathway, possibly including KLHDC8B. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
As a histone deacetylase inhibitor, it affects chromatin remodeling and gene expression, potentially increasing the expression of proteins like KLHDC8B involved in response to cellular stress. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
By activating retinoic acid receptors, it can alter gene expression profiles, possibly leading to upregulation of proteins involved in cell differentiation and stress response, including potentially KLHDC8B. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $168.00 | ||
A specific autophagy inhibitor that may lead to the accumulation of ubiquitinated proteins, potentially increasing the expression of proteins involved in proteostasis, like KLHDC8B. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $172.00 $305.00 | 66 | |
An inducer of the unfolded protein response (UPR), it can cause upregulation of genes involved in protein folding and degradation, potentially impacting KLHDC8B expression as part of the UPR. | ||||||