KIAA1024L_A730017C20Rik Activators
Chemical activators of MINAR2 include a variety of compounds that influence the NOTCH signaling pathway, which is integral to the activation of this protein. Dibenzazepine directly binds to the NOTCH2 receptor and promotes the release of the NOTCH intracellular domain, which in turn activates MINAR2 through conformational changes. Valproic Acid operates by inhibiting histone deacetylase, leading to transcriptional activation of NOTCH target genes and subsequent MINAR2 activation. Resveratrol's engagement with Sirtuin 1 results in the deacetylation of the NOTCH1 intracellular domain, which may similarly affect MINAR2 activity by modulating NOTCH signaling. DAPT, as a gamma-secretase inhibitor, leads to the accumulation of NOTCH receptors on the cell surface, thus possibly increasing ligand-mediated activation of MINAR2.
Curcumin modulates the NOTCH signaling pathway by promoting the cleavage of NOTCH receptors, thereby potentially enhancing MINAR2 activity. Sulforaphane's activation of Nrf2 can lead to the upregulation of NOTCH pathway components, which may further activate MINAR2. In response to DNA damage, Etoposide can initiate a cellular response that activates the NOTCH signaling pathway, enhancing MINAR2 activity. Compounds such as Isosilybin are reported to influence NOTCH signaling, possibly by promoting the expression and activity of its key components, thereby facilitating MINAR2 activation. Quercetin activates the PI3K/Akt pathway, intersecting with NOTCH signaling; this activation can lead to the phosphorylation of NOTCH and subsequent MINAR2 enhancement. Retinol can affect the NOTCH signaling pathway through its metabolites, influencing gene expression and possibly MINAR2 activation. The active components within St. John's Wort can upregulate the NOTCH signaling pathway, which may include increased MINAR2 activity. Lastly, Bay K 8644, as an L-type calcium channel agonist, can induce increased intracellular calcium levels, which may enhance the activation of MINAR2 through its role as a secondary messenger in NOTCH signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Dibenzazepine (Deshydroxy LY 411575) | 209984-56-5 | sc-207554 sc-207554A | 2 mg 5 mg | $100.00 $260.00 | 4 | |
Dibenzazepine is a known NOTCH signaling pathway activator, which by binding to the NOTCH2 receptor, promotes the release of the NOTCH intracellular domain and subsequent activation of membrane integral NOTCH2 associated receptor 2 (MINAR2) through a conformational change. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic Acid can enhance the NOTCH signaling pathway by inhibiting histone deacetylase (HDAC), which leads to hyperacetylation of histones near NOTCH target genes, facilitating transcription and indirectly leading to activation of MINAR2 as NOTCH signaling components are upregulated. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol can activate Sirtuin 1, which can then deacetylate NOTCH1 intracellular domain, a process that may similarly affect NOTCH2 and its associated receptor MINAR2 by enhancing its signaling capacity and functional activation. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $99.00 $335.00 $836.00 $2099.00 | 47 | |
DAPT is a gamma-secretase inhibitor that can paradoxically lead to MINAR2 activation by accumulating NOTCH receptors at the cell surface, thus potentially increasing the likelihood of ligand-mediated activation of MINAR2. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin has been shown to modulate the NOTCH signaling pathway, which may include promoting the cleavage of NOTCH receptors and thus enhancing the activation of MINAR2 by increasing its signaling potential. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane can activate Nrf2, which may upregulate NOTCH signaling pathway components and in turn activate MINAR2 by enhancing signaling through the pathway. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide induces DNA damage response which can lead to the activation of NOTCH signaling pathway as part of the cellular response machinery, potentially increasing the functional activity of MINAR2. | ||||||
Silybin | 22888-70-6 | sc-202812 sc-202812A sc-202812B sc-202812C | 1 g 5 g 10 g 50 g | $54.00 $112.00 $202.00 $700.00 | 6 | |
Isosilybin has been reported to influence NOTCH signaling. As such, it can enhance the cleavage and activation of MINAR2 by promoting the expression and activity of key components of the NOTCH pathway. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin can activate PI3K/Akt pathway, which intersects with NOTCH signaling. Akt can phosphorylate NOTCH, which could enhance the activation of MINAR2 by increasing the signaling through the NOTCH pathway. | ||||||
Vitamin A | 68-26-8 | sc-280187 sc-280187A | 1 g 10 g | $377.00 $2602.00 | ||
Retinol metabolites can regulate gene expression through retinoic acid receptors and may influence the NOTCH signaling pathway, leading to the activation of MINAR2. | ||||||