KIAA0652 Inhibitors
KIAA0652 inhibitors represent a chemical class that specifically targets the protein encoded by the KIAA0652 gene, also known as SPATA6. This gene is involved in various cellular functions, including cytoskeletal organization and intracellular signaling. Inhibitors of KIAA0652 are typically small molecules designed to interact with the SPATA6 protein or its regulatory pathways, blocking its activity. These inhibitors can modify processes such as protein-protein interactions or phosphorylation events that rely on KIAA0652, providing a tool for understanding its biological roles. Chemical structures of KIAA0652 inhibitors may vary, but they generally feature motifs that enhance their binding affinity and specificity to the target protein. Such molecules can be used in various biochemical assays to dissect the mechanisms by which KIAA0652 influences cellular dynamics.
In biochemical research, KIAA0652 inhibitors can be utilized to explore the functional consequences of disrupting this protein's activity. They can serve as useful molecular probes in studies aimed at elucidating the role of KIAA0652 in cellular pathways like cytoskeletal rearrangement or vesicular trafficking. By applying these inhibitors in vitro, researchers can observe how the loss of KIAA0652 function affects cellular processes, allowing for the mapping of downstream effects and interacting partners. This class of inhibitors plays a key role in defining the protein's specific contributions to broader cellular networks and provides insights into the molecular underpinnings of the pathways associated with KIAA0652.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Autophagy Inhibitor, 3-MA | 5142-23-4 | sc-205596 sc-205596A | 50 mg 500 mg | $65.00 $261.00 | 113 | |
Inhibits class III PI3K, which is involved in the initiation of autophagy, leading to the inhibition of Autophagy-related protein 13 assembly and function. | ||||||
Spautin-1 | 1262888-28-7 | sc-507306 | 10 mg | $168.00 | ||
Targets the ubiquitin-specific peptidases USP10 and USP13, leading to the degradation of VPS34 PI3K complexes, thereby inhibiting Autophagy-related protein 13-dependent autophagy initiation. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Inhibits PI3K family members, including those involved in autophagy induction, thus inhibiting the Autophagy-related protein 13 function in autophagosome formation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
Inhibits class I PI3K, which indirectly inhibits autophagy and may lead to reduced Autophagy-related protein 13 activity due to impaired autophagy signaling. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
Accumulates in lysosomes, impairing their function and indirectly inhibiting Autophagy-related protein 13 by preventing autophagosome-lysosome fusion. | ||||||
Bafilomycin A1 | 88899-55-2 | sc-201550 sc-201550A sc-201550B sc-201550C | 100 µg 1 mg 5 mg 10 mg | $98.00 $255.00 $765.00 $1457.00 | 280 | |
Specifically inhibits V-ATPase, which is essential for lysosomal acidification; this inhibition results in blockade of autophagosome-lysosome fusion, affecting Autophagy-related protein 13 function. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $57.00 | 1 | |
Similar to Chloroquine, it raises the pH of lysosomes and inhibits autophagosome-lysosome fusion, thereby inhibiting Autophagy-related protein 13 function. | ||||||
SAR405 | 1523406-39-4 | sc-507416 | 1 mg | $125.00 | ||
A PI3K/VPS34 inhibitor, which would impair the initiation of autophagy, leading to inhibition of autophagy-related processes involving Autophagy-related protein 13. | ||||||
Lys05 | 1391426-24-6 | sc-507532 | 5 mg | $140.00 | ||
A lysosomal autophagy inhibitor, a more potent derivative of chloroquine, which would lead to inhibition of Autophagy-related protein 13 by blocking autophagosome degradation. | ||||||
MHY1485 | 326914-06-1 | sc-507522 | 10 mg | $140.00 | ||
An mTOR activator which would lead to inhibition of autophagy, thereby reducing the functional role of Autophagy-related protein 13 in autophagosome formation. | ||||||