KDELC2 Inhibitors
KDELC2 inhibitors comprise a group of chemical compounds that interfere with the function of the protein by disrupting specific pathways and processes in glycosylation and glycoprotein trafficking.
Swainsonine and Kifunensine target the mannosidase enzymes, which are essential for the trimming of mannose residues during N-glycan maturation, a process in which KDELC2 is implicated. The impairment of glycan maturation due to these inhibitors can lead to the functional inhibition of KDELC2. Similarly, Benzyl-α-GalNAc and Castanospermine inhibit the O-glycosylation and glucosidase activities, respectively, causing a build-up of misprocessed glycoproteins and disrupting the glycan structures that KDELC2 typically handles.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Swainsonine | 72741-87-8 | sc-201362 sc-201362C sc-201362A sc-201362D sc-201362B | 1 mg 2 mg 5 mg 10 mg 25 mg | $135.00 $246.00 $619.00 $799.00 $1796.00 | 6 | |
An inhibitor of alpha-mannosidase II, which is essential for the modification of N-glycans in the Golgi apparatus. Inhibition of this enzyme can impair N-glycan maturation, which KDELC2 is known to be involved in, leading to a decrease in KDELC2-dependent glycoprotein quality control and trafficking. | ||||||
Kifunensine | 109944-15-2 | sc-201364 sc-201364A sc-201364B sc-201364C | 1 mg 5 mg 10 mg 100 mg | $132.00 $529.00 $1005.00 $6125.00 | 25 | |
A mannosidase I inhibitor that leads to the accumulation of high-mannose glycoproteins by preventing the trimming of mannose residues. KDELC2 is associated with the processing of these residues, and its function can be inhibited due to the accumulation of misprocessed glycoproteins. | ||||||
Benzyl-2-acetamido-2-deoxy-α-D-galactopyranoside | 3554-93-6 | sc-203427 sc-203427A | 100 mg 1 g | $350.00 $3122.00 | 2 | |
An inhibitor of O-glycosylation that prevents the addition of N-acetylgalactosamine to serine and threonine residues. KDELC2, which is involved in glycoprotein processing, may be functionally inhibited due to the disruption of proper O-glycan synthesis and subsequent glycoprotein misfolding. | ||||||
Castanospermine | 79831-76-8 | sc-201358 sc-201358A | 100 mg 500 mg | $180.00 $620.00 | 10 | |
A glucosidase inhibitor that blocks the trimming of glucose residues from N-linked glycans during glycoprotein folding. KDELC2's function in glycoprotein quality control could be inhibited as a result of improper glycan processing and the accumulation of glycoproteins with faulty glycan structures. | ||||||
Deoxynojirimycin | 19130-96-2 | sc-201369 sc-201369A | 1 mg 5 mg | $72.00 $142.00 | ||
An inhibitor of glucosidase I and II, enzymes responsible for cleaving glucose residues from N-linked oligosaccharides. This can affect KDELC2's role in glycoprotein folding by leading to the accumulation of improperly folded glycoproteins. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
An N-glycosylation inhibitor that blocks the addition of N-linked glycosylation on nascent proteins. This can lead to ER stress and UPR, which can inhibit KDELC2's activity by preventing proper glycoprotein folding and maturation. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
An inhibitor of ADP-ribosylation factor (ARF), leading to Golgi disassembly. This affects KDELC2 by disrupting the Golgi apparatus where KDELC2 functions, inhibiting proper glycoprotein processing and trafficking. | ||||||
Monensin A | 17090-79-8 | sc-362032 sc-362032A | 5 mg 25 mg | $152.00 $515.00 | ||
A sodium ionophore that disrupts Golgi function by altering the pH and ion gradients. This can inhibit KDELC2's role in the Golgi by affecting glycoprotein maturation and trafficking. | ||||||
Colchicine | 64-86-8 | sc-203005 sc-203005A sc-203005B sc-203005C sc-203005D sc-203005E | 1 g 5 g 50 g 100 g 500 g 1 kg | $98.00 $315.00 $2244.00 $4396.00 $17850.00 $34068.00 | 3 | |
An inhibitor of microtubule polymerization, disrupting intracellular transport. KDELC2's function in glycoprotein trafficking can be indirectly inhibited due to the impairment of microtubule-dependent transport within the Golgi. | ||||||
Nocodazole | 31430-18-9 | sc-3518B sc-3518 sc-3518C sc-3518A | 5 mg 10 mg 25 mg 50 mg | $58.00 $83.00 $140.00 $242.00 | 38 | |
A microtubule-depolymerizing agent that disrupts cytoskeletal dynamics. This can lead to the inhibition of KDELC2 by impairing glycoprotein trafficking and processing within the Golgi apparatus. | ||||||