KDELC2 Inhibitors

KDELC2 inhibitors comprise a group of chemical compounds that interfere with the function of the protein by disrupting specific pathways and processes in glycosylation and glycoprotein trafficking.

Swainsonine and Kifunensine target the mannosidase enzymes, which are essential for the trimming of mannose residues during N-glycan maturation, a process in which KDELC2 is implicated. The impairment of glycan maturation due to these inhibitors can lead to the functional inhibition of KDELC2. Similarly, Benzyl-α-GalNAc and Castanospermine inhibit the O-glycosylation and glucosidase activities, respectively, causing a build-up of misprocessed glycoproteins and disrupting the glycan structures that KDELC2 typically handles.