JAZF1 Activators
JAZF1 activators belong to a distinctive chemical class that primarily interacts with the Junctophilin-4 (JAZF1) protein, modulating its activity within cellular processes. The Junctophilin family of proteins is renowned for their pivotal role in facilitating the formation and maintenance of junctions between the endoplasmic reticulum (ER) and the plasma membrane, a critical aspect of cellular function. JAZF1, in particular, is recognized for its involvement in diverse cellular functions beyond the established ER-plasma membrane junction maintenance. It is intricately associated with gene regulation, cell cycle progression, and metabolic pathways, rendering it a key player in cellular homeostasis.
Chemical compounds classified as JAZF1 activators demonstrate a distinctive molecular profile that enables them to bind selectively to the JAZF1 protein, triggering conformational changes or modifying its interactions with other cellular components. Through these interactions, JAZF1 activators modulate cellular responses and contribute to the intricate network of regulatory mechanisms governing various cellular functions. Understanding the specific molecular mechanisms underlying JAZF1 activation by these compounds is crucial for unraveling their broader implications in cellular physiology. As research advances, the exploration of JAZF1 activators may shed light on novel insights into the molecular intricacies of cellular processes, offering potential avenues for further investigation in the realms of basic science and molecular biology.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
An HDAC inhibitor that may indirectly activate JAZF1 by enhancing chromatin remodeling, potentially leading to increased gene expression regulation. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
A DNA methyltransferase inhibitor that could indirectly activate JAZF1 by disrupting DNA methylation patterns, thereby promoting epigenetic activation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor that may indirectly activate JAZF1 by modulating downstream processes involved in cellular signaling and gene expression activation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K/Akt inhibitor that may indirectly activate JAZF1 by perturbing the PI3K/Akt pathway, facilitating cellular signaling and gene expression activation. | ||||||
XAV939 | 284028-89-3 | sc-296704 sc-296704A sc-296704B | 1 mg 5 mg 50 mg | $36.00 $117.00 $525.00 | 26 | |
A Wnt/β-Catenin pathway modulator that may indirectly activate JAZF1 by influencing the Wnt pathway, potentially instigating transcriptional activation. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
An AMPK activator that may indirectly activate JAZF1 by orchestrating cellular energy regulation and potentially facilitating gene expression activation. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
An NF-κB inhibitor that may indirectly activate JAZF1 by suppressing inflammatory responses, potentially prompting gene expression activation. | ||||||
DAPT | 208255-80-5 | sc-201315 sc-201315A sc-201315B sc-201315C | 5 mg 25 mg 100 mg 1 g | $40.00 $120.00 $480.00 $2141.00 | 47 | |
A Notch pathway inhibitor that may indirectly activate JAZF1 by modulating the Notch pathway, potentially prompting transcriptional activation. | ||||||
Rosiglitazone | 122320-73-4 | sc-202795 sc-202795A sc-202795C sc-202795D sc-202795B | 25 mg 100 mg 500 mg 1 g 5 g | $120.00 $326.00 $634.00 $947.00 $1259.00 | 38 | |
A PPARγ agonist that may indirectly activate JAZF1 by influencing PPARγ-related gene expression and metabolism, potentially prompting activation. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
A proteasome inhibitor that may indirectly activate JAZF1 by affecting protein degradation pathways, potentially impacting protein stability and function, ultimately leading to activation. | ||||||