JAZF1 Antibody (C-11): sc-376503
- JAZF1 Antibody (C-11) is a mouse monoclonal IgG2a κ JAZF1 antibody, cited in 5 publications, provided at 200 µg/ml
- raised against amino acids 1-243 representing full length JAZF1 of human origin
- JAZF1 Antibody (C-11) is recommended for detection of JAZF1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including bovine
- Anti-JAZF1 Antibody (C-11) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-376503 X, 200 µg/0.1 ml)
- m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for JAZF1 Antibody (C-11) for WB applications. These reagents are now offered in bundles with JAZF1 Antibody (C-11) (see ordering information below).
QUICK LINKS
JAZF1 Antibody (C-11) is a mouse monoclonal IgG2a kappa light chain antibody that detects JAZF1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-JAZF1 antibody (C-11) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. JAZF1, also known as juxtaposed with another zinc finger protein 1, TIP27 (TAK1-interacting protein 27), or ZNF802 (zinc finger protein 802), is a 243 amino acid protein primarily localized in the nucleus and features three C2H2-type zinc finger domains. This structural characteristic allows JAZF1 to interact with specific DNA sequences and other proteins, playing a significant role in transcriptional regulation. JAZF1 functions as a transcriptional repressor, particularly in its interaction with nuclear orphan receptor TR4, which is essential for modulating gene expression involved in various cellular processes. Chromosomal aberrations in the gene encoding JAZF1 have been implicated in the development of endometrial stromal tumors, highlighting JAZF1′s potential role in carcinogenesis. The JAZF1 gene is located on human chromosome 7, a region containing over 1,000 genes and associated with several genetic disorders, including Osteogenesis imperfecta and Williams-Beuren syndrome, underscoring JAZF1′s importance in both normal physiology and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
JAZF1 Antibody (C-11) References:
- Frequent fusion of the JAZF1 and JJAZ1 genes in endometrial stromal tumors. | Koontz, JI., et al. 2001. Proc Natl Acad Sci U S A. 98: 6348-53. PMID: 11371647
- Molecular detection of JAZF1-JJAZ1 gene fusion in endometrial stromal neoplasms with classic and variant histology: evidence for genetic heterogeneity. | Huang, HY., et al. 2004. Am J Surg Pathol. 28: 224-32. PMID: 15043312
- TIP27: a novel repressor of the nuclear orphan receptor TAK1/TR4. | Nakajima, T., et al. 2004. Nucleic Acids Res. 32: 4194-204. PMID: 15302918
- Consistent rearrangement of chromosomal band 6p21 with generation of fusion genes JAZF1/PHF1 and EPC1/PHF1 in endometrial stromal sarcoma. | Micci, F., et al. 2006. Cancer Res. 66: 107-12. PMID: 16397222
- Molecular analysis of the JAZF1-JJAZ1 gene fusion by RT-PCR and fluorescence in situ hybridization in endometrial stromal neoplasms. | Nucci, MR., et al. 2007. Am J Surg Pathol. 31: 65-70. PMID: 17197920
- Effects of rearrangement and allelic exclusion of JJAZ1/SUZ12 on cell proliferation and survival. | Li, H., et al. 2007. Proc Natl Acad Sci U S A. 104: 20001-6. PMID: 18077430
- An endometrial stromal sarcoma cell line with the JAZF1/PHF1 chimera. | Panagopoulos, I., et al. 2008. Cancer Genet Cytogenet. 185: 74-7. PMID: 18722875
- Common variants in the JAZF1 gene associated with height identified by linkage and genome-wide association analysis. | Johansson, A., et al. 2009. Hum Mol Genet. 18: 373-80. PMID: 18952825
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JAZF1 Antibody (C-11) | sc-376503 | 200 µg/ml | $322.00 | |||
JAZF1 Antibody (C-11): m-IgGκ BP-HRP Bundle | sc-522979 | 200 µg Ab, 40 µg BP | $361.00 | |||
JAZF1 Antibody (C-11): m-IgG2a BP-HRP Bundle | sc-546129 | 200 µg Ab; 10 µg BP | $361.00 | |||
JAZF1 Antibody (C-11) X | sc-376503 X | 200 µg/0.1 ml | $322.00 | |||
JAZF1 Antibody (C-11) AC | sc-376503 AC | 500 µg/ml, 25% agarose | $424.00 | |||
JAZF1 Antibody (C-11) HRP | sc-376503 HRP | 200 µg/ml | $322.00 | |||
JAZF1 Antibody (C-11) FITC | sc-376503 FITC | 200 µg/ml | $336.00 | |||
JAZF1 Antibody (C-11) PE | sc-376503 PE | 200 µg/ml | $349.00 | |||
JAZF1 Antibody (C-11) Alexa Fluor® 488 | sc-376503 AF488 | 200 µg/ml | $364.00 | |||
JAZF1 Antibody (C-11) Alexa Fluor® 546 | sc-376503 AF546 | 200 µg/ml | $364.00 | |||
JAZF1 Antibody (C-11) Alexa Fluor® 594 | sc-376503 AF594 | 200 µg/ml | $364.00 | |||
JAZF1 Antibody (C-11) Alexa Fluor® 647 | sc-376503 AF647 | 200 µg/ml | $364.00 | |||
JAZF1 Antibody (C-11) Alexa Fluor® 680 | sc-376503 AF680 | 200 µg/ml | $364.00 | |||
JAZF1 Antibody (C-11) Alexa Fluor® 790 | sc-376503 AF790 | 200 µg/ml | $364.00 |