Date published: 2026-7-22

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JAK Antibodies

Santa Cruz Biotechnology supplies a comprehensive collection of JAK Antibodies for advanced research in signal transduction and immune response. JAK Antibodies are compatible with multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Janus kinases (JAKs) are crucial components of cytokine signaling pathways, playing a significant role in the regulation of immune responses, hematopoiesis, and cell proliferation. Dysregulation of JAK activity is associated with numerous diseases, including autoimmune disorders and cancers, making research in this area vital for understanding disease mechanisms and developing targeted therapies. JAK monoclonal antibodies enable researchers to investigate specific protein interactions and signaling cascades within cellular pathways. Studying JAK signaling networks helps reveal their role in normal physiological processes and disease states. Understanding JAK-mediated pathways contributes to the development of novel therapeutic strategies for various medical conditions. The high-quality monoclonal antibodies from Santa Cruz Biotechnology support researchers worldwide in advancing scientific knowledge and therapeutic discoveries in JAK-related research.

SEE ALSO...

JAK Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

JAK1 Antibody (B-3)

sc-376996mouse IgG1 κ270-375 (h)WB, IP, IF, ELISAh
24
(7)

JAK1 Antibody (A-9)

sc-1677mouse IgG2b κ796-815 (m)WB, IP, IF, IHC(P), ELISAm, r, h
26
(12)

JAK2 Antibody (C-10)

sc-390539mouse IgG2b κ752-780 (m)WB, IP, IF, ELISAm, r, h
53
(28)

JAK3 Antibody (B-12)

sc-6932mouse IgA1105-1124 (h)WB, IP, IF, IHC(P), ELISAm, r, h
13
(15)

JAK3 Antibody (A1-14-16)

sc-56921mouse IgG2a1076-1100 (m)WB, IP, IF, IHC(P)m, r, h
2
(2)

JAK3 Antibody (3F228)

sc-71461mouse IgG2a κ1076-1100 (m)WB, IP, IF, IHC(P)m, r, h

new

(1)

JAK siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

JAK1 siRNA (h)

sc-35719hGene SilencingN/A
5
(0)

JAK1 shRNA Plasmid (h)

sc-35719-SHhGene SilencingPuromycin
5
(0)

JAK1 shRNA (h) Lentiviral Particles

sc-35719-VhGene SilencingPuromycin
5
(0)

JAK1 siRNA (m)

sc-35720mGene SilencingN/A
1
(0)

JAK1 shRNA Plasmid (m)

sc-35720-SHmGene SilencingPuromycin
1
(0)

JAK1 shRNA (m) Lentiviral Particles

sc-35720-VmGene SilencingPuromycin
1
(0)

JAK2 siRNA (h)

sc-39099hGene SilencingN/A
12
(2)

JAK2 shRNA Plasmid (h)

sc-39099-SHhGene SilencingPuromycin
12
(2)

JAK2 shRNA (h) Lentiviral Particles

sc-39099-VhGene SilencingPuromycin
12
(2)

JAK2 siRNA (m)

sc-39100mGene SilencingN/A
4
(0)

JAK2 shRNA Plasmid (m)

sc-39100-SHmGene SilencingPuromycin
4
(0)

JAK2 shRNA (m) Lentiviral Particles

sc-39100-VmGene SilencingPuromycin
4
(0)

JAK2 siRNA (r)

sc-270385rGene SilencingN/A
5
(0)

JAK2 shRNA Plasmid (r)

sc-270385-SHrGene SilencingPuromycin
5
(0)

JAK2 shRNA (r) Lentiviral Particles

sc-270385-VrGene SilencingPuromycin
5
(0)

JAK3 siRNA (h)

sc-29379hGene SilencingN/A
3
(0)

JAK3 shRNA Plasmid (h)

sc-29379-SHhGene SilencingPuromycin
3
(0)

JAK3 shRNA (h) Lentiviral Particles

sc-29379-VhGene SilencingPuromycin
3
(0)

JAK3 siRNA (m)

sc-35721mGene SilencingN/A
1
(0)

JAK3 shRNA Plasmid (m)

sc-35721-SHmGene SilencingPuromycin
1
(0)

JAK3 shRNA (m) Lentiviral Particles

sc-35721-VmGene SilencingPuromycin
1
(0)

JAK CRISPR Knockout (KO) and HDR Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

JAK1 CRISPR/Cas9 KO Plasmid (h)

sc-400439Gene Knockouth0
(0)

JAK1 HDR Plasmid (h)

sc-400439-HDRHomology Directed Repairh0
(0)

JAK1 CRISPR/Cas9 KO Plasmid (m)

sc-421199Gene Knockoutm0
(0)

JAK1 HDR Plasmid (m)

sc-421199-HDRHomology Directed Repairm0
(0)

JAK2 CRISPR/Cas9 KO Plasmid (h2)

sc-400246-KO-2Gene Knockouth0
(0)

JAK2 HDR Plasmid (h2)

sc-400246-HDR-2Homology Directed Repairh0
(0)

JAK2 CRISPR/Cas9 KO Plasmid (m)

sc-421200Gene Knockoutm0
(0)

JAK2 HDR Plasmid (m)

sc-421200-HDRHomology Directed Repairm0
(0)

JAK3 CRISPR/Cas9 KO Plasmid (h2)

sc-400835-KO-2Gene Knockouth0
(0)

JAK3 HDR Plasmid (h2)

sc-400835-HDR-2Homology Directed Repairh0
(0)

JAK CRISPR Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

JAK1 Double Nickase Plasmid (h)

sc-400439-NICGene Knockouth0
(0)

JAK1 Double Nickase Plasmid (h2)

sc-400439-NIC-2Gene Knockouth0
(0)

JAK1 Double Nickase Plasmid (m)

sc-421199-NICGene Knockoutm0
(0)

JAK2 Double Nickase Plasmid (h)

sc-400246-NICGene Knockouth0
(0)

JAK2 Double Nickase Plasmid (h2)

sc-400246-NIC-2Gene Knockouth0
(0)

JAK2 Double Nickase Plasmid (m)

sc-421200-NICGene Knockoutm0
(0)

JAK2 Double Nickase Plasmid (m2)

sc-421200-NIC-2Gene Knockoutm0
(0)

JAK3 Double Nickase Plasmid (h)

sc-400835-NICGene Knockouth0
(0)

JAK3 Double Nickase Plasmid (h2)

sc-400835-NIC-2Gene Knockouth0
(0)

JAK CRISPR Activation Plasmids and Lentiviral Particles

Empty Table HeaderProduct NameCATALOG #APPLICATIONSSpeciesCitationsRATING

JAK1 CRISPR Activation Plasmid (h)

sc-400439-ACTGene Activationh0
(0)

JAK1 CRISPR Activation Plasmid (m)

sc-421199-ACTGene Activationm0
(0)

JAK2 CRISPR Activation Plasmid (h)

sc-400246-ACTGene Activationh0
(0)

JAK2 CRISPR Activation Plasmid (h2)

sc-400246-ACT-2Gene Activationh0
(0)

JAK2 Lentiviral Activation Particles (h)

sc-400246-LACGene Activationh0
(0)

JAK3 CRISPR Activation Plasmid (h)

sc-400835-ACTGene Activationh0
(0)

JAK3 CRISPR Activation Plasmid (h2)

sc-400835-ACT-2Gene Activationh0
(0)