JAK3 Antibody (3F228): sc-71461
- JAK3 Antibody (3F228) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 1076-1100 of JAK3 of mouse origin
- recommended for detection of JAK3 of mouse, rat and human origin by WB, IP, IF and IHC(P); non cross-reactive with JAK 1, JAK 2 or Tyk 2
- See JAK3 (B-12): sc-6932 for JAK3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for JAK3 Antibody (3F228). This work is in progress.
QUICK LINKS
JAK3 Antibody (3F228) is a mouse monoclonal IgG2a antibody that detects JAK3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Anti-JAK3 antibody (3F228) plays a crucial role in the regulation of the JAK/Stat signaling pathway, which is essential for maintaining a balanced immune response. JAK3 is primarily located in the cytoplasm of hematopoietic cells, where JAK3 associates with cytokine receptors and is activated upon cytokine binding. This localization is vital because JAK3 can rapidly respond to extracellular signals, facilitating the phosphorylation of Stat transcription factors. Once activated, these Stat factors dimerize and translocate to the nucleus, where Stat factors regulate the transcription of genes involved in immune cell proliferation, differentiation, and survival. Dysregulation of JAK3 activity can lead to various immune disorders, making JAK3 an important target for therapeutic intervention in inflammatory diseases. JAK3 (3F228) antibody is an invaluable tool for researchers studying the intricate mechanisms of immune regulation and the potential for developing targeted anti-inflammatory therapies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JAK3 Antibody (3F228) | sc-71461 | 200 µg/ml | $322.00 |