JAK3 Antibody (A1-14-16): sc-56921
- JAK3 Antibody (A1-14-16) is a mouse monoclonal IgG2a, cited in 2 publications, provided at 200 µg/ml
- raised against amino acids 1076-1100 of JAK3 of mouse origin
- recommended for detection of JAK3 of mouse, rat and human origin by WB, IP, IF and IHC(P); non cross-reactive with JAK 1, JAK 2 or Tyk 2
- See JAK3 (B-12): sc-6932 for JAK3 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for JAK3 Antibody (A1-14-16). This work is in progress.
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JAK3 Antibody (A1-14-16) is a mouse monoclonal IgG2a antibody that detects JAK3 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. JAK3, or Janus kinase 3, plays a crucial role in the signaling pathways of the immune system, particularly in the lympho-hematopoietic system, where JAK3 regulates various cellular functions downstream of activated cytokine receptors. JAK3 is primarily located in the cytoplasm, where JAK3 interacts with cytokine receptor-associated proteins, facilitating the phosphorylation of Stat transcription factors. This interaction is vital for the transduction of signals that lead to the transcription of genes involved in immune responses, including those that promote cell proliferation, differentiation, and survival. The proper functioning of JAK3 is essential for maintaining a balanced immune response, and dysregulation of JAK3 activity can lead to autoimmune diseases and other inflammatory conditions. By targeting JAK3, researchers can explore therapeutic strategies aimed at modulating immune responses, making anti-JAK3 antibody (A1-14-16) an invaluable tool for studying immune signaling pathways and developing anti-inflammatory therapies.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JAK3 Antibody (A1-14-16) | sc-56921 | 200 µg/ml | $322.00 |