JAK Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
JAK Inhibitor I | 457081-03-7 | sc-204021 sc-204021A | 500 µg 1 mg | $153.00 $332.00 | 59 | |
JAK Inhibitor I is a selective modulator that targets Janus kinases, crucial for signal transduction in various cellular processes. Its unique binding affinity disrupts the phosphorylation of specific substrates, thereby influencing downstream signaling cascades. The compound exhibits distinct kinetic properties, allowing for rapid interaction with JAK enzymes, which can lead to altered cellular responses. Additionally, its structural features facilitate unique molecular interactions that can provide insights into regulatory mechanisms within cellular environments. | ||||||
Stat3 Inhibitor III, WP1066 | 857064-38-1 | sc-203282 | 10 mg | $132.00 | 72 | |
Stat3 Inhibitor III, WP1066, functions as a potent JAK inhibitor by disrupting the phosphorylation cascade essential for signal transducer and activator of transcription 3 (Stat3) activation. Its unique binding affinity alters the conformational state of Stat3, preventing its dimerization and nuclear translocation. This compound exhibits a distinctive interaction with the SH2 domain, influencing downstream gene expression and cellular responses. The compound's selective inhibition showcases its potential to finely tune signaling pathways. | ||||||
AG-490 | 133550-30-8 | sc-202046C sc-202046A sc-202046B sc-202046 | 5 mg 50 mg 25 mg 10 mg | $82.00 $323.00 $219.00 $85.00 | 35 | |
AG-490 acts as a selective JAK inhibitor, primarily targeting the JAK2 pathway. It interferes with the phosphorylation of specific tyrosine residues, thereby modulating the activation of downstream signaling molecules. This compound exhibits a unique ability to disrupt the interaction between JAK and its associated receptors, leading to altered cellular signaling dynamics. Its kinetic profile suggests a rapid onset of action, making it a valuable tool for studying JAK-mediated pathways. | ||||||
AZD1480 | 935666-88-9 | sc-364735 sc-364735A | 5 mg 50 mg | $122.00 $1051.00 | 11 | |
AZD1480 is a selective JAK inhibitor that exhibits a unique mechanism of action by binding to the ATP-binding site of Janus kinases, effectively blocking their catalytic activity. This inhibition alters the conformational dynamics of the enzyme, impacting its interaction with substrate proteins. The compound's distinct molecular architecture enhances its specificity, allowing for targeted modulation of inflammatory pathways. Its kinetic profile suggests a rapid onset of action, influencing cellular signaling networks in a nuanced manner. | ||||||
Gö 6976 | 136194-77-9 | sc-221684 | 500 µg | $223.00 | 8 | |
Gö 6976 acts as a selective JAK inhibitor, characterized by its ability to disrupt the phosphorylation process essential for JAK activation. This compound uniquely interacts with the ATP-binding site of JAK, leading to altered enzyme kinetics and reduced downstream signaling. Its structural attributes facilitate a strong binding affinity, effectively blocking the interaction with associated cytokine receptors. This modulation of JAK activity influences various cellular pathways, impacting overall cellular behavior. | ||||||
Cucurbitacin I | 2222-07-3 | sc-203010 | 1 mg | $250.00 | 9 | |
Cucurbitacin I functions as a potent JAK inhibitor, exhibiting a unique mechanism by binding to the JAK enzyme and preventing its activation. This compound selectively alters the conformational dynamics of JAK, impacting its interaction with various cytokine receptors. The resulting inhibition of signal transducer pathways leads to significant changes in gene expression. Its distinct structural features contribute to its specificity and efficacy in modulating cellular responses. | ||||||
JAK2 Inhibitor III, SD-1029 | 118372-34-2 | sc-221773 | 10 mg | $278.00 | 5 | |
JAK2 Inhibitor III, SD-1029, is a potent inhibitor that selectively targets the JAK2 enzyme, showcasing a unique mechanism of action through its interaction with the enzyme's regulatory domains. This compound alters the conformational dynamics of JAK2, leading to a significant reduction in its catalytic activity. By stabilizing specific protein-protein interactions, it effectively modulates the signaling cascades associated with JAK2, influencing cellular responses and gene expression patterns. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $56.00 $169.00 | 8 | |
PP242 is a selective inhibitor of the JAK family of kinases, exhibiting a unique binding affinity that disrupts the ATP-binding site. This compound alters the phosphorylation state of target proteins, thereby influencing downstream signaling pathways. Its kinetic profile reveals a rapid onset of action, with a notable impact on the conformational stability of JAK proteins. By modulating these interactions, PP242 effectively alters cellular signaling dynamics, leading to distinct biological outcomes. | ||||||
Cercosporamide | 131436-22-1 | sc-202095 sc-202095A | 500 µg 2.5 mg | $300.00 $1200.00 | 2 | |
Cercosporamide functions as a potent JAK inhibitor, characterized by its ability to selectively engage with the enzyme's active site. This compound exhibits unique molecular interactions that stabilize the inactive conformation of JAK proteins, effectively hindering their catalytic activity. Its reaction kinetics suggest a moderate binding affinity, allowing for a nuanced modulation of signaling pathways. By influencing the structural dynamics of JAK, Cercosporamide alters cellular responses in a distinctive manner. | ||||||