ISGF-3γ p48 Inhibitors
ISGF-3γ p48 Inhibitors, within the realm of molecular biology and pharmacology, represent a class of chemical compounds designed to target and modulate the activity of the ISGF-3γ p48 complex, which is an integral component of the interferon signaling pathway. The ISGF-3γ p48 complex plays a pivotal role in the innate immune response, particularly in the activation of interferon-stimulated genes (ISGs) responsible for mounting an antiviral defense. These inhibitors are engineered with the intent of either suppressing or altering the function of ISGF-3γ p48 to influence downstream gene expression, thus potentially impacting the body's immune response to viral infections.
Typically, ISGF-3γ p48 Inhibitors function by interacting with specific molecular targets within the ISGF-3γ p48 complex. By doing so, they can impede the complex's ability to translocate into the nucleus of the cell and bind to the promoter regions of ISGs. This disruption can lead to a cascade of events that ultimately result in the downregulation of interferon-induced genes, potentially affecting the host's ability to combat viral infections. The development and study of ISGF-3γ p48 Inhibitors represent an area of active research aimed at elucidating the intricate mechanisms governing the interferon signaling pathway and may hold promise for future applications in understanding immune regulation and the development of targeted interventions.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may inhibit ISGF-3γ p48 expression by modulating the JAK-STAT signaling pathway, potentially affecting the phosphorylation status of STAT1 and STAT2, and thereby impacting the formation of the ISGF-3 complex. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol has been reported to exhibit anti-inflammatory properties and may modulate various signaling pathways, including JAK-STAT. Its potential role in inhibiting ISGF-3γ p48 expression could be related to these activities. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid, may downregulate the expression of ISGF-3γ p48 by inhibiting STAT1 and STAT2 phosphorylation, potentially disrupting the ISGF-3 complex formation. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein, an isoflavone, has been shown to inhibit tyrosine kinases, potentially affecting the JAK-STAT pathway and, consequently, the expression of ISGF-3γ p48 as part of the ISGF-3 complex. | ||||||
Silymarin group, mixture of isomers | 65666-07-1 | sc-301806 | 50 g | $319.00 | ||
Silymarin may inhibit ISGF-3γ p48 expression indirectly by modulating oxidative stress and inflammation, which are known to be associated with the JAK-STAT signaling pathway. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a major component of green tea, has been reported to have anti-inflammatory and antioxidant properties. It may potentially inhibit ISGF-3γ p48 expression by modulating the JAK-STAT signaling pathway. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane, found in cruciferous vegetables, may have a role in inhibiting ISGF-3γ p48 expression through its known effects on anti-inflammatory and antioxidant pathways, which could influence the JAK-STAT signaling pathway. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin is a flavonoid that may inhibit ISGF-3γ p48 expression by modulating various signaling pathways, including JAK-STAT, and affecting the phosphorylation status of STAT proteins. | ||||||
Indirubin | 479-41-4 | sc-201531 sc-201531A | 5 mg 25 mg | $112.00 $515.00 | 4 | |
Indirubin, a compound found in Chinese medicinal herbs, has been reported to inhibit tyrosine kinases. Its potential inhibition of ISGF-3γ p48 expression could be through the modulation of the JAK-STAT signaling pathway. | ||||||
NDGA (Nordihydroguaiaretic acid) | 500-38-9 | sc-200487 sc-200487A sc-200487B | 1 g 5 g 25 g | $107.00 $376.00 $2147.00 | 3 | |
NDGA has antioxidant properties and has been shown to inhibit lipoxygenases. Its potential role in inhibiting ISGF-3γ p48 expression could be related to its ability to modulate inflammatory responses, impacting the JAK-STAT pathway. | ||||||