ISGF-3γ p48 Antibody (H-10): sc-365893

ISGF-3γ p48 Antibody (H-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects ISGF-3 gamma p48 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Anti-ISGF-3γ p48 antibody (H-10) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. ISGF-3 gamma p48 protein plays a crucial role in interferon signaling pathway, functioning as a transcription factor that regulates expression of interferon-stimulated genes. ISGF-3 gamma p48 is essential for immune response, helping mediate effects of interferons, which are critical for antiviral defense and immune regulation. p48 subunit forms a complex with Stat1 and Stat2, collectively known as ISGF-3, which translocates to nucleus upon activation and binds to specific DNA elements to initiate transcription. Understanding ISGF-3 gamma p48 function is vital for elucidating mechanisms of immune response and developing therapeutic strategies for diseases where interferon signaling is disrupted.

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ISGF-3γ p48 Antibody (H-10) References:

1. p48 (ISGF-3gamma) is involved in interferon-alpha-induced suppression of hepatitis B virus enhancer-1 activity.  |  Nakao, K., et al. 1999. J Biol Chem. 274: 28075-8. PMID: 10497156
2. Suppression of interferon response gene expression in cells persistently infected with mumps virus, and restoration from its suppression by treatment with ribavirin.  |  Fujii, N., et al. 1999. Virus Res. 65: 175-85. PMID: 10581390
3. P48 is a predictive marker for outcome of postoperative interferon-alpha treatment in patients with hepatitis B virus infection-related hepatocellular carcinoma.  |  Qian, YB., et al. 2006. Cancer. 107: 1562-9. PMID: 16948122
4. Proliferation-associated 2G4 P48 is stabilized by malignant T-cell amplified sequence 1 and promotes the proliferation of head and neck squamous cell carcinoma.  |  Sun, L., et al. 2023. J Dent Sci. 18: 1588-1597. PMID: 37799877
5. Structure and regulation of the human interferon regulatory factor 1 (IRF-1) and IRF-2 genes: implications for a gene network in the interferon system.  |  Harada, H., et al. 1994. Mol Cell Biol. 14: 1500-9. PMID: 7507207
6. Molecular cloning of APRF, a novel IFN-stimulated gene factor 3 p91-related transcription factor involved in the gp130-mediated signaling pathway.  |  Akira, S., et al. 1994. Cell. 77: 63-71. PMID: 7512451
7. A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma.  |  Shuai, K., et al. 1993. Science. 261: 1744-6. PMID: 7690989
8. Stat4, a novel gamma interferon activation site-binding protein expressed in early myeloid differentiation.  |  Yamamoto, K., et al. 1994. Mol Cell Biol. 14: 4342-9. PMID: 8007943
9. Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6.  |  Zhong, Z., et al. 1994. Science. 264: 95-8. PMID: 8140422
10. Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins.  |  Darnell, JE., et al. 1994. Science. 264: 1415-21. PMID: 8197455
11. Transcription factor p91 interacts with the epidermal growth factor receptor and mediates activation of the c-fos gene promoter.  |  Fu, XY. and Zhang, JJ. 1993. Cell. 74: 1135-45. PMID: 8402883
12. ISGF3 gamma p48, a specificity switch for interferon activated transcription factors.  |  Bluyssen, AR., et al. 1996. Cytokine Growth Factor Rev. 7: 11-7. PMID: 8864350

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-ISGF-3γ p48 Antibody (H-10) has 13 citations in a variety of scientific publications.

Primary antibodies like Anti-ISGF-3γ p48 Antibody (H-10) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

ISGF-3γ p48 Antibody (H-10) Specifications

Alternate Product Name: IRF9

Product Clone Name: H-10

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 113-255

Epitope Target: ISGF-3Γ p48

Epitope Species: human

Product Reactivity/Detection: ISGF-3γ p48

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 13 citations in various scientific publications

Available Conjugates/Forms for ISGF-3γ p48 Antibody (H-10): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin, X: TransCruz Reagent