IRS-1 Activators
IRS-1 Activators are a class of chemical compounds that have the potential to upregulate or enhance the activity of the Insulin Receptor Substrate 1 (IRS-1) protein. IRS-1 is a cytoplasmic protein that serves as a critical intermediary in insulin signaling pathways. The protein becomes phosphorylated upon insulin binding to its receptor, creating docking sites for other signaling molecules like phosphoinositide 3-kinase (PI3K) and Grb2. This sequence of interactions subsequently leads to various cellular processes such as glucose uptake, metabolism, and cell survival. IRS-1 plays a significant role in mediating the body's response to insulin, a hormone central to regulating carbohydrate and fat metabolism in the body.
The chemical compounds classified as IRS-1 Activators generally work by different mechanisms to enhance the expression or functionality of IRS-1. Some compounds may stimulate the pathways that lead to IRS-1 phosphorylation, while others may protect IRS-1 from degradation or inactivation, thereby sustaining its activity. Compounds like resveratrol, metformin, and berberine, for example, have been investigated for their potential to activate IRS-1 through various signaling pathways such as AMP-activated protein kinase (AMPK) or SIRT1 activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol may enhance IRS-1 expression by activating the SIRT1 pathway. It acts as a mimetic of calorie restriction and may have implications in modulating insulin sensitivity. | ||||||
Berberine | 2086-83-1 | sc-507337 | 250 mg | $90.00 | 1 | |
Berberine has been shown to upregulate IRS-1 expression via AMPK activation. This may help in improving cellular response to insulin. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin may increase IRS-1 expression by reducing oxidative stress and inflammation, thereby potentially enhancing insulin signaling. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin has been shown to activate the Nrf2 pathway, which could be responsible for inducing IRS-1 expression, contributing to enhanced insulin signaling. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a phytoestrogen that may upregulate IRS-1 through estrogen receptor pathways, thus potentially improving insulin signaling. | ||||||
Fisetin | 528-48-3 | sc-276440 sc-276440A sc-276440B sc-276440C sc-276440D | 50 mg 100 mg 500 mg 1 g 100 g | $51.00 $77.00 $102.00 $153.00 $2856.00 | 7 | |
Fisetin is believed to increase IRS-1 expression by reducing inflammation and oxidative stress, which can improve cellular insulin sensitivity. | ||||||
Caffeic Acid | 331-39-5 | sc-200499 sc-200499A | 1 g 5 g | $31.00 $61.00 | 1 | |
Caffeic acid may induce IRS-1 expression by inhibiting the NF-κB pathway, thereby potentially improving insulin signaling. | ||||||
Ellagic Acid, Dihydrate | 476-66-4 | sc-202598 sc-202598A sc-202598B sc-202598C | 500 mg 5 g 25 g 100 g | $57.00 $93.00 $240.00 $713.00 | 8 | |
Ellagic acid may enhance IRS-1 expression by acting as an antioxidant and anti-inflammatory agent, potentially aiding in insulin signaling. | ||||||
Luteolin | 491-70-3 | sc-203119 sc-203119A sc-203119B sc-203119C sc-203119D | 5 mg 50 mg 500 mg 5 g 500 g | $26.00 $50.00 $99.00 $150.00 $1887.00 | 40 | |
Luteolin is believed to induce IRS-1 expression through its anti-inflammatory and antioxidant properties, potentially enhancing insulin sensitivity. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $97.00 $212.00 $500.00 | 11 | |
Kaempferol may upregulate IRS-1 expression by inhibiting oxidative stress and activating AMPK, potentially improving insulin sensitivity. | ||||||