Date published: 2025-10-6

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IRS-1 Antibodies

Santa Cruz Biotechnology offers a broad range of IRS-1 monoclonal antibodies for research focused on understanding insulin receptor substrate 1 (IRS-1) protein. IRS-1 Antibodies are available for multiple applications, including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). IRS-1 plays a critical role in insulin signaling and glucose metabolism, acting as a key mediator between the insulin receptor and downstream signaling pathways. The proper function of IRS-1 is essential for maintaining metabolic homeostasis, and its dysregulation has been implicated in conditions such as insulin resistance and type 2 diabetes. Understanding IRS-1's role in cellular processes is crucial for developing therapeutic strategies targeting metabolic disorders. Researchers can explore IRS-1's involvement in various cellular pathways using specific monoclonal antibodies conjugated with horseradish peroxidase (HRP), phycoerythrin (PE), or fluorescein isothiocyanate (FITC). IRS-1 monoclonal antibodies enable detailed investigation of protein-protein interactions and signaling cascades in metabolic research. IRS-1 monoclonal antibodies support reliable experimental outcomes across multiple applications. Santa Cruz Biotechnology monoclonal antibodies for IRS-1 contribute to advancing our understanding of metabolic diseases and potential therapeutic interventions.

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IRS-1 Antibodies

Empty Table HeaderProduct NameCATALOG #ISOTYPEEPITOPEAPPLICATIONSSpeciesCitationsRATING

IRS-1 Antibody (H-7)

sc-515017mouse IgG1 κ2-25 (h)WB, IP, IF, ELISAh
9
(6)

IRS-1 Antibody (E-12)

sc-8038mouse IgG2a κ905-1070 (h)WB, IP, IF, FCM, ELISAm, r, h
78
(16)

IRS-1 CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

IRS-1 CRISPR/Cas9 KO Plasmid (h2)

sc-400096-KO-2hGene KnockoutGFP0
(0)

IRS-1 HDR Plasmid (h2)

sc-400096-HDR-2hHomology Directed RepairPuromycin0
(0)

IRS-1 Double Nickase Plasmid (h)

sc-400096-NIChGene KnockoutPuromycin0
(0)

IRS-1 Double Nickase Plasmid (h2)

sc-400096-NIC-2hGene KnockoutPuromycin0
(0)

IRS-1 CRISPR/Cas9 KO Plasmid (m2)

sc-421150-KO-2mGene KnockoutGFP0
(0)

IRS-1 Double Nickase Plasmid (m)

sc-421150-NICmGene KnockoutPuromycin0
(0)

IRS-1 Double Nickase Plasmid (m2)

sc-421150-NIC-2mGene KnockoutPuromycin0
(0)

IRS-1 CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

IRS-1 CRISPR Activation Plasmid (h)

sc-400096-ACThGene ActivationPuro, Blast, Hygro0
(0)

IRS-1 CRISPR Activation Plasmid (h2)

sc-400096-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

IRS-1 Lentiviral Activation Particles (h)

sc-400096-LAChGene ActivationPuro, Blast, Hygro0
(0)

IRS-1 Lentiviral Activation Particles (h2)

sc-400096-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

IRS-1 CRISPR Activation Plasmid (m)

sc-421150-ACTmGene ActivationPuro, Blast, Hygro0
(0)

IRS-1 CRISPR Activation Plasmid (m2)

sc-421150-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

IRS-1 Lentiviral Activation Particles (m)

sc-421150-LACmGene ActivationPuro, Blast, Hygro0
(0)

IRS-1 Lentiviral Activation Particles (m2)

sc-421150-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

IRS-1 siRNA, shRNA Plasmid and shRNA Lentiviral Particle Gene Silencers

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

IRS-1 siRNA (h)

sc-29376hGene SilencingN/A
9
(0)

IRS-1 siRNA (h2)

sc-44268hGene SilencingN/A0
(0)

IRS-1 shRNA Plasmid (h)

sc-29376-SHhGene SilencingPuromycin
9
(0)

IRS-1 shRNA Plasmid (h2)

sc-44268-SHhGene SilencingPuromycin0
(0)

IRS-1 shRNA (h) Lentiviral Particles

sc-29376-VhGene SilencingPuromycin
9
(0)

IRS-1 shRNA (h2) Lentiviral Particles

sc-44268-VhGene SilencingPuromycin0
(0)

IRS-1 siRNA (m)

sc-29377mGene SilencingN/A
5
(0)

IRS-1 shRNA Plasmid (m)

sc-29377-SHmGene SilencingPuromycin
5
(0)

IRS-1 shRNA (m) Lentiviral Particles

sc-29377-VmGene SilencingPuromycin
5
(0)

IRS-1 siRNA (r)

sc-155987rGene SilencingN/A
1
(0)

IRS-1 shRNA Plasmid (r)

sc-155987-SHrGene SilencingPuromycin
1
(0)

IRS-1 shRNA (r) Lentiviral Particles

sc-155987-VrGene SilencingPuromycin
1
(0)