IRF-2BP1 Inhibitors
Chemical inhibitors of IRF-2BP1 can exert their effects by targeting specific cellular pathways that are crucial for the protein's function. Aurora kinase inhibitors such as ZM-447439 and VX-680 (Tozasertib) can disrupt cell cycle regulation in which IRF-2BP1 is involved. These inhibitors can lead to improper spindle assembly and chromosome alignment, consequently impairing the cell cycle progression that IRF-2BP1 helps to regulate. Similarly, checkpoint kinase inhibitors like PF-477736 and AZD7762 can halt cell cycle progression and DNA damage repair pathways, processes that are also potentially regulated by IRF-2BP1. By doing so, these chemicals can indirectly inhibit the regulatory functions of IRF-2BP1 in cell cycle checkpoints and DNA repair mechanisms.
Additionally, chemicals such as BI 2536, which targets Polo-like kinase 1 (Plk1), can induce mitotic arrest, indirectly affecting IRF-2BP1's associated roles in mitosis. Cyclin-dependent kinase (CDK) inhibitors, including Roscovitine (CYC202), Flavopiridol, Alsterpaullone, Palbociclib (PD 0332991), and Dinaciclib, can arrest cell cycle progression at various checkpoints. This can lead to the indirect inhibition of IRF-2BP1's function in regulating the cell cycle. Moreover, the selective Aurora B kinase inhibitor AZD1152-HQPA can interfere with chromosome alignment and segregation, a critical phase where IRF-2BP1 might have a role, thus functionally inhibiting it. Lastly, AT7519, a multi-CDK inhibitor, can disrupt a range of cellular processes including the cell cycle, which can lead to the functional inhibition of IRF-2BP1's role in these processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
ZM-447439 | 331771-20-1 | sc-200696 sc-200696A | 1 mg 10 mg | $153.00 $356.00 | 15 | |
ZM-447439 is an Aurora kinase inhibitor. IRF-2BP1 has been implicated in cell cycle regulation, where Aurora kinases play critical roles. Inhibition of Aurora kinases by ZM-447439 can disrupt the cell cycle and indirectly inhibit the function of IRF-2BP1 in promoting cell cycle progression. | ||||||
Tozasertib | 639089-54-6 | sc-358750 sc-358750A | 25 mg 50 mg | $62.00 $87.00 | 4 | |
VX-680 is another Aurora kinase inhibitor. By targeting the Aurora kinases, this chemical disrupts proper spindle assembly and chromosome alignment, processes in which IRF-2BP1 may be functionally involved, leading to an inhibition of IRF-2BP1's cell cycle regulatory functions. | ||||||
PF 477736 | 952021-60-2 | sc-362781 sc-362781A | 5 mg 25 mg | $115.00 $431.00 | ||
PF-477736 is a checkpoint kinase inhibitor. Checkpoint kinases coordinate cell cycle progression and DNA repair mechanisms. IRF-2BP1's involvement in cell cycle control suggests that inhibiting checkpoint kinases could indirectly inhibit IRF-2BP1 function. | ||||||
AZD7762 | 860352-01-8 | sc-364423 | 2 mg | $107.00 | ||
AZD7762, another checkpoint kinase inhibitor, can halt cell cycle progression and DNA damage repair pathways. By doing so, it can indirectly inhibit IRF-2BP1's role in cell cycle and DNA repair regulation. | ||||||
BI 2536 | 755038-02-9 | sc-364431 sc-364431A | 5 mg 50 mg | $151.00 $525.00 | 8 | |
BI 2536 is a Plk1 inhibitor. Polo-like kinase 1 is essential for various stages of mitosis. Inhibiting Plk1 can lead to mitotic arrest, thereby functionally inhibiting IRF-2BP1's associated roles in cell cycle progression. | ||||||
Roscovitine | 186692-46-6 | sc-24002 sc-24002A | 1 mg 5 mg | $94.00 $265.00 | 42 | |
Roscovitine is a cyclin-dependent kinase inhibitor. As CDKs are vital for cell cycle transitions, their inhibition can indirectly affect IRF-2BP1's function by disrupting the cell cycle control in which IRF-2BP1 participates. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $259.00 | 41 | |
Flavopiridol is a potent CDK inhibitor that can arrest cell cycle progression. Through this mechanism, it can indirectly inhibit the function of IRF-2BP1 in cell cycle regulation. | ||||||
Alsterpaullone | 237430-03-4 | sc-202453 sc-202453A | 1 mg 5 mg | $68.00 $312.00 | 2 | |
Alsterpaullone is a CDK inhibitor with similar effects to Flavopiridol, indirectly inhibiting IRF-2BP1 by disrupting the regulated progression of the cell cycle. | ||||||
Palbociclib | 571190-30-2 | sc-507366 | 50 mg | $321.00 | ||
Palbociclib selectively inhibits CDK4/6, leading to a G1 phase cell cycle arrest. Since IRF-2BP1 is implicated in cell cycle regulation, this can indirectly inhibit its function. | ||||||
Dinaciclib | 779353-01-4 | sc-364483 sc-364483A | 5 mg 25 mg | $247.00 $888.00 | 1 | |
Dinaciclib is a broad CDK inhibitor that can cause cell cycle arrest, thereby indirectly inhibiting the function of IRF-2BP1 in cell cycle control. | ||||||