IRF-2BP1 Antibody (A-10): sc-373899
- IRF-2BP1 Antibody (A-10) is a mouse monoclonal IgG1 κ IRF-2BP1 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 327-355 within an internal region of IRF-2BP1 of human origin
- IRF-2BP1 Antibody (A-10) is recommended for detection of IRF-2BP1 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including equine
- TransCruz reagent for ChIP application (sc-373899 X, 200 µg/0.1 ml)
- Anti-IRF-2BP1 Antibody (A-10) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for IRF-2BP1 Antibody (A-10) for WB applications. These reagents are now offered in bundles with IRF-2BP1 Antibody (A-10) (see ordering information below).
IRF-2BP1 Antibody (A-10) is a mouse monoclonal IgG1 kappa light chain antibody that detects IRF-2BP1 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IRF-2BP1 (A-10) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IRF-2BP1, also known as interferon regulatory factor 2 binding protein 1, plays a crucial role in gene expression regulation, particularly in immune responses. IRF-2BP1 acts as a corepressor of IRF-2, inhibiting both enhancer activation and basal transcription, which is vital for maintaining gene expression balance in response to interferon signaling. IRF-2BP1 is located in the nucleus, where IRF-2BP1 interacts with various transcription factors, including JDP2 (Jun-dimerization protein 2), enhancing polyubiquitination, which is essential for regulating stability and activity of these factors. A C-terminal RING-type zinc finger domain in IRF-2BP1 is critical for interaction with BRCA1 associated protein 1 (BAP1), linking IRF-2BP1 to pathways involved in DNA repair and cell cycle regulation. Encoded by a gene on human chromosome 19, IRF-2BP1 is part of a densely packed genomic region, underscoring potential significance in various cellular processes and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IRF-2BP1 Antibody (A-10) References:
- Identification of novel co-repressor molecules for Interferon Regulatory Factor-2. | Childs, KS. and Goodbourn, S. 2003. Nucleic Acids Res. 31: 3016-26. PMID: 12799427
- IRF-2 regulates NF-kappaB activity by modulating the subcellular localization of NF-kappaB. | Chae, M., et al. 2008. Biochem Biophys Res Commun. 370: 519-24. PMID: 18395009
- IRF2-binding protein-1 is a JDP2 ubiquitin ligase and an inhibitor of ATF2-dependent transcription. | Kimura, M. 2008. FEBS Lett. 582: 2833-7. PMID: 18671972
- Interferon regulatory factor-2 induces megakaryopoiesis in mouse bone marrow hematopoietic cells. | Masumi, A., et al. 2009. FEBS Lett. 583: 3493-500. PMID: 19818776
- Structurally similar but functionally distinct factors, IRF-1 and IRF-2, bind to the same regulatory elements of IFN and IFN-inducible genes. | Harada, H., et al. 1989. Cell. 58: 729-39. PMID: 2475256
- Recognition DNA sequences of interferon regulatory factor 1 (IRF-1) and IRF-2, regulators of cell growth and the interferon system. | Tanaka, N., et al. 1993. Mol Cell Biol. 13: 4531-8. PMID: 7687740
- The oncogenic transcription factor IRF-2 possesses a transcriptional repression and a latent activation domain. | Yamamoto, H., et al. 1994. Oncogene. 9: 1423-8. PMID: 8152803
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IRF-2BP1 Antibody (A-10) | sc-373899 | 200 µg/ml | $322.00 | |||
IRF-2BP1 Antibody (A-10): m-IgG Fc BP-HRP Bundle | sc-529601 | 200 µg Ab; 10 µg BP | $361.00 | |||
IRF-2BP1 Antibody (A-10): m-IgGκ BP-HRP Bundle | sc-522547 | 200 µg Ab, 40 µg BP | $361.00 | |||
IRF-2BP1 Antibody (A-10) X | sc-373899 X | 200 µg/0.1 ml | $322.00 | |||
IRF-2BP1 Antibody (A-10) AC | sc-373899 AC | 500 µg/ml, 25% agarose | $424.00 | |||
IRF-2BP1 Antibody (A-10) HRP | sc-373899 HRP | 200 µg/ml | $322.00 | |||
IRF-2BP1 Antibody (A-10) FITC | sc-373899 FITC | 200 µg/ml | $336.00 | |||
IRF-2BP1 Antibody (A-10) PE | sc-373899 PE | 200 µg/ml | $349.00 | |||
IRF-2BP1 Antibody (A-10) Alexa Fluor® 488 | sc-373899 AF488 | 200 µg/ml | $364.00 | |||
IRF-2BP1 Antibody (A-10) Alexa Fluor® 546 | sc-373899 AF546 | 200 µg/ml | $364.00 | |||
IRF-2BP1 Antibody (A-10) Alexa Fluor® 594 | sc-373899 AF594 | 200 µg/ml | $364.00 | |||
IRF-2BP1 Antibody (A-10) Alexa Fluor® 647 | sc-373899 AF647 | 200 µg/ml | $364.00 | |||
IRF-2BP1 Antibody (A-10) Alexa Fluor® 680 | sc-373899 AF680 | 200 µg/ml | $364.00 | |||
IRF-2BP1 Antibody (A-10) Alexa Fluor® 790 | sc-373899 AF790 | 200 µg/ml | $364.00 | |||
IRF-2BP1 (A-10) Neutralizing Peptide | sc-373899 P | 100 µg/0.5 ml | $69.00 |