IP3KB Inhibitors
IP3KB, also known as inositol 1,4,5-trisphosphate 3-kinase B, is a crucial enzyme involved in the regulation of intracellular calcium signaling pathways. Its primary function is to phosphorylate inositol 1,4,5-trisphosphate (IP3) to produce inositol 1,3,4,5-tetrakisphosphate (IP4), thereby terminating IP3-mediated calcium release from intracellular stores. This process plays a pivotal role in modulating various cellular processes, including cell proliferation, differentiation, and apoptosis.
Inhibition of IP3KB can occur through multiple mechanisms, both directly and indirectly. Direct inhibitors may target the enzymatic activity of IP3KB, disrupting its ability to phosphorylate IP3 and regulate intracellular calcium signaling. Indirect inhibitors, on the other hand, may modulate upstream signaling pathways or cellular processes that regulate IP3KB expression or activity. These inhibitors can interfere with phosphoinositide signaling pathways, calcium homeostasis, hormone receptor signaling, and transcriptional regulation, ultimately leading to the suppression or inhibition of IP3KB function. Understanding the diverse mechanisms of IP3KB inhibition provides insights into the regulation of intracellular calcium signaling.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
PI3K inhibitor that disrupts phosphoinositide signaling pathways, inhibiting IP3KB indirectly by blocking the production of its substrate, phosphatidylinositol (3,4,5)-trisphosphate (PIP3). | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
PI3K inhibitor that suppresses the production of PIP3, indirectly inhibiting IP3KB by interfering with the signaling cascade downstream of its activation by phosphoinositide 3-kinase (PI3K). | ||||||
TMB-8 • HCl | 53464-72-5 | sc-3522 sc-3522A | 10 mg 50 mg | $43.00 $129.00 | 10 | |
Calcium channel blocker that inhibits IP3-induced calcium release from intracellular stores, indirectly suppressing IP3KB activity by reducing the availability of its substrate, inositol trisphosphate (IP3). | ||||||
2-APB | 524-95-8 | sc-201487 sc-201487A | 20 mg 100 mg | $28.00 $53.00 | 37 | |
Modulator of IP3R calcium channels that interferes with IP3-mediated calcium release, indirectly inhibiting IP3KB activity by disrupting the signaling pathway downstream of IP3-induced calcium mobilization. | ||||||
Raloxifene | 84449-90-1 | sc-476458 | 1 g | $802.00 | 3 | |
Selective estrogen receptor modulator (SERM) that can suppress IP3KB expression through estrogen receptor-mediated mechanisms, indirectly inhibiting IP3KB activity by reducing its expression levels. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $62.00 $85.00 $356.00 | 155 | |
Inhibitor of NF-κB activation that can indirectly inhibit IP3KB expression and activity by blocking the transcriptional regulation of genes involved in the NF-κB signaling pathway, which regulates IP3KB expression. | ||||||
LY 303511 | 154447-38-8 | sc-202215 sc-202215A | 1 mg 5 mg | $67.00 $278.00 | 3 | |
Derivative of LY294002 that inhibits PI3K/Akt signaling, indirectly suppressing IP3KB activity by interfering with downstream signaling events regulated by the PI3K pathway, which can modulate IP3KB expression and function. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Chemotherapeutic agent that can indirectly inhibit IP3KB expression and activity through various mechanisms, including DNA damage-induced activation of signaling pathways that regulate IP3KB expression and function. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
SERCA inhibitor that disrupts calcium homeostasis by blocking calcium reuptake into the endoplasmic reticulum, indirectly inhibiting IP3KB activity by altering calcium signaling pathways that regulate its activation. | ||||||
Bisphenol A | 80-05-7 | sc-391751 sc-391751A | 100 mg 10 g | $300.00 $490.00 | 5 | |
Endocrine disruptor that can indirectly influence IP3KB activity through estrogen receptor-mediated mechanisms, potentially altering IP3KB expression and function by interfering with hormonal signaling pathways. | ||||||