IP-10 Activators
IP-10 Activators belong to a category of chemical compounds that are implicated in the modulation or enhancement of the biological activity of Interferon-gamma-induced Protein 10 (IP-10), also known as CXCL10 (C-X-C motif chemokine ligand 10). IP-10 is a chemokine, a type of small protein secreted by various cell types in response to the presence of interferon-gamma (IFN-γ) or other pro-inflammatory signals. This chemokine plays a significant role in the immune system by attracting and activating immune cells to sites of inflammation, infection, or tissue damage. IP-10 Activators, by targeting IP-10, have the ability to influence the chemotactic and immunomodulatory functions of this chemokine.
IP-10 is known for its role in orchestrating immune responses, primarily by recruiting T cells and monocytes to areas where their presence is required. It does so by binding to its cognate receptor, CXCR3, which is expressed on the surface of these immune cells. IP-10's function is not limited to immune cell recruitment; it also contributes to the regulation of inflammation, angiogenesis, and tissue repair processes. IP-10 Activators are thought to interact with IP-10, altering its structure or activity, which could lead to changes in its ability to bind to CXCR3 and activate downstream signaling pathways. Understanding the mechanisms by which IP-10 Activators modulate IP-10's actions is crucial for shedding light on the broader context of immune regulation and inflammation within the body. These activators hold promise for unraveling the complex interplay between chemokines and the immune system.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a labdane diterpene from the Indian Coleus plant, known to activate adenylyl cyclase, thereby increasing cAMP levels. This may indirectly influence cytokine production and affect IP-10 expression. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, the principal curcuminoid of turmeric, modulates several signaling pathways, including NF-κB. It plays a role in the regulation of IP-10 and other chemokines. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol, found in grapes, exerts anti-inflammatory effects and can modulate cytokine expression. Its impact on NF-κB may indirectly influence IP-10 levels. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
DL-Sulforaphane, from cruciferous vegetables, activates Nrf2 and modulates NF-κB. These pathways can affect chemokines including IP-10. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $37.00 $146.00 | 3 | |
Piperine, an alkaloid from black pepper, affects various signaling pathways involved in cytokine production, potentially influencing IP-10 expression. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a plant flavonoid, modulates inflammatory pathways, potentially affecting chemokine expression and activity, including IP-10. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin, a flavone found in many plants, is known for its anti-inflammatory properties and may indirectly affect IP-10 expression through modulation of signaling pathways. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, a major component of green tea, influences inflammatory pathways that can impact chemokine regulation, including IP-10. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $96.00 $160.00 $240.00 $405.00 | 26 | |
Capsaicin, the active component in chili peppers, affects several signaling molecules and may have an indirect influence on chemokine expression, including IP-10. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein, an isoflavone from soy, impacts various cellular signaling pathways and its role in modulating inflammation can indirectly affect IP-10 levels. | ||||||