Integrin αIIIb Inhibitors
Integrin αIIIb inhibitors are a class of chemical compounds specifically designed to target and inhibit the activity of the integrin αIIIb subunit, a key component of certain integrin receptors that mediate cell adhesion, signaling, and interactions with the extracellular matrix (ECM). Integrins are heterodimeric receptors formed by the pairing of an alpha (α) and beta (β) subunit, which together facilitate critical cellular functions such as adhesion to the ECM, cell migration, and intercellular communication. Integrin αIIIb is most commonly paired with a β subunit to form a functional receptor that binds ligands like fibrinogen, vitronectin, and fibronectin. These binding interactions are vital for cellular processes such as maintaining tissue integrity, supporting cell movement, and contributing to the dynamic regulation of the cytoskeleton. Inhibitors of integrin αIIIb are designed to disrupt these ligand-receptor interactions, blocking the ability of the integrin to participate in cellular adhesion and signaling pathways.
The design of integrin αIIIb inhibitors typically focuses on interfering with the binding sites within the αIIIb subunit that are essential for ligand recognition and interaction. These inhibitors may work by occupying the receptor's active site, thereby preventing its engagement with ECM components or by locking the integrin in an inactive conformation that cannot undergo the necessary changes for ligand binding. Binding interactions between integrin αIIIb inhibitors and the receptor usually involve non-covalent forces such as hydrogen bonding, van der Waals interactions, and hydrophobic interactions, ensuring high specificity and stability in blocking receptor function. Through the use of integrin αIIIb inhibitors, researchers can explore how this specific integrin subunit influences cell adhesion, cytoskeletal organization, and migration. This class of inhibitors is valuable for studying the broader roles of integrins in cellular dynamics and how integrin-mediated interactions with the ECM affect various biological processes such as wound healing, tissue regeneration, and cell signaling.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
By inhibiting DNA methyltransferase, 5-Azacytidine could cause demethylation of the ITGA3 gene promoter, leading to a decrease in transcription initiation and subsequent downregulation of Integrin αIIIb synthesis. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A could hinder histone deacetylation, causing hyperacetylation of histones near the ITGA3 gene. This alteration in chromatin structure may repress the initiation of transcription, resulting in a decrease of Integrin αIIIb production. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $210.00 $242.00 $1434.00 | 2 | |
This compound may interfere with the removal of acetyl groups from histones associated with the ITGA3 gene, leading to a condensed chromatin state and reduced transcriptional activity, thereby decreasing Integrin αIIIb levels. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Through inhibition of DNA methyltransferases, 5-Aza-2′-Deoxycytidine could lead to reduced methylation levels at the promoter of the ITGA3 gene, consequently decreasing the expression of the Integrin αIIIb protein. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 free base | sc-202651 | 5 mg | $148.00 | 4 | |
BIX-01294 could inhibit histone methyltransferases specific to the histone marks that promote the expression of the ITGA3 gene, potentially leading to a repressed state and reduced levels of Integrin αIIIb. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG 108 might block DNA methyltransferases, preventing the methylation of the ITGA3 promoter. This hypomethylation might result in a tightly packed chromatin configuration and the subsequent downregulation of Integrin αIIIb expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
This HDAC inhibitor could prevent deacetylation of histones at the ITGA3 locus, possibly resulting in decreased transcriptional activity and lower Integrin αIIIb expression. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram's ability to chelate copper might disrupt the function of copper-dependent enzymes and transcription factors that are necessary for ITGA3 transcription, which could result in decreased Integrin αIIIb expression. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $260.00 $925.00 | 5 | |
As a selective inhibitor of the p300/CBP histone acetyltransferase, C646 could lead to decreased acetylation of histones at the ITGA3 promoter, suppressing transcription and thus reducing Integrin αIIIb levels. | ||||||
α-Lipoic Acid | 1077-28-7 | sc-202032 sc-202032A sc-202032B sc-202032C sc-202032D | 5 g 10 g 250 g 500 g 1 kg | $68.00 $120.00 $208.00 $373.00 $702.00 | 3 | |
By altering cellular redox states, α-Lipoic Acid may interfere with signaling pathways that are essential for the transcriptional activation of the ITGA3 gene, thereby leading to a decrease in Integrin αIIIb protein synthesis. | ||||||