Integrin α3b/ITGA3B Antibody (54B3): sc-59967

Integrin αIIIb Antibody (54B3) is a mouse monoclonal IgG1 antibody that detects Integrin αIIIb protein of mouse, rat, and human origin by western blotting (WB) and immunofluorescence (IF). Anti-Integrin αIIIb antibody (54B3) is available as the non-conjugated format. Integrins are crucial for various cellular processes, functioning as transmembrane receptors that mediate cell adhesion to the extracellular matrix and facilitate communication between cells. Integrin αIIIb protein, also known as very late activation antigen 3 (VLA-3), plays a significant role in cell signaling and adhesion, which are vital for processes such as wound healing, immune response, and tissue development. Integrin αIIIb protein is primarily located on the cell surface, where heterodimer formation with β subunits allows interaction with ligands like fibrinogen and components of the extracellular matrix, including fibronectin and collagen. Proper localization of Integrin αIIIb protein is essential for function, enabling effective mediation of cell-matrix interactions and signal transduction that influence cell behavior. Integrin αIIIb antibody (54B3) helps researchers gain insights into the mechanisms of cell adhesion and migration, which are critical in understanding various physiological and pathological processes.

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Integrin α3b/ITGA3B Antibody (54B3) References:

1. Ligand binding promotes the entropy-driven oligomerization of integrin alpha IIb beta 3.  |  Hantgan, RR., et al. 2003. J Biol Chem. 278: 3417-26. PMID: 12426312
2. Integrin alpha IIb beta 3-dependent calcium signals regulate platelet-fibrinogen interactions under flow. Involvement of phospholipase C gamma 2.  |  Goncalves, I., et al. 2003. J Biol Chem. 278: 34812-22. PMID: 12832405
3. SHIP1 and Lyn Kinase Negatively Regulate Integrin alpha IIb beta 3 signaling in platelets.  |  Maxwell, MJ., et al. 2004. J Biol Chem. 279: 32196-204. PMID: 15166241
4. Disabled-2 is a negative regulator of integrin alpha(IIb)beta(3)-mediated fibrinogen adhesion and cell signaling.  |  Huang, CL., et al. 2004. J Biol Chem. 279: 42279-89. PMID: 15280374
5. Integrins: versatility, modulation, and signaling in cell adhesion.  |  Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
6. Integrins and signal transduction pathways: the road taken.  |  Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
7. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function.  |  Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
8. Epithelial integrins.  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
9. Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation.  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069