INO80E Inhibitors
INO80E inhibitors are a class of chemical compounds designed to specifically target the INO80 complex subunit E (INO80E), a key component of the INO80 chromatin-remodeling complex. The INO80 complex is involved in the regulation of DNA structure by modifying chromatin through ATP-dependent remodeling. This process is critical for facilitating access to DNA during replication, transcription, repair, and recombination. INO80E is a subunit that plays a supportive role in the overall function of the INO80 complex, contributing to its ability to modulate chromatin and influence the accessibility of DNA. INO80E inhibitors are designed to disrupt the function of this subunit, interfering with the complex's ability to remodel chromatin and thereby altering the dynamics of DNA-associated processes.
The design of INO80E inhibitors typically involves targeting key functional domains or active sites within the INO80E subunit that are essential for its interaction with other components of the INO80 complex. These inhibitors may block the ATPase activity necessary for chromatin remodeling or disrupt the structural integrity of the complex. Binding interactions between INO80E inhibitors and the protein can involve hydrogen bonds, hydrophobic interactions, or electrostatic forces, ensuring specificity and stability in the inhibition. By blocking the activity of INO80E, researchers can study the precise role of this subunit in chromatin remodeling and how its disruption affects DNA-related processes such as transcription and repair. INO80E inhibitors serve as valuable tools for investigating the intricate mechanisms by which chromatin structure influences gene regulation and cellular function, offering a deeper understanding of chromatin dynamics and the contribution of specific subunits like INO80E to these essential processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hydroxyurea | 127-07-1 | sc-29061 sc-29061A | 5 g 25 g | $78.00 $260.00 | 18 | |
Hydroxyurea stalls DNA replication by inhibiting ribonucleotide reductase, leading to a decrease in dNTPs. This can indirectly affect INO80E, as the protein's function in DNA repair and replication might be compromised due to the lack of necessary substrates. | ||||||
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin forms intra- and inter-strand DNA crosslinks that hinder the DNA replication process. This could indirectly inhibit INO80E activity by creating a hostile environment for its function. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $58.00 $186.00 $94.00 | 21 | |
Camptothecin inhibits topoisomerase I, trapping it in a covalent complex with DNA and leading to DNA breaks during replication. This could potentially disturb INO80E's function in DNA repair and replication. | ||||||
Aphidicolin | 38966-21-1 | sc-201535 sc-201535A sc-201535B | 1 mg 5 mg 25 mg | $84.00 $306.00 $1104.00 | 30 | |
Aphidicolin inhibits DNA polymerase α and δ, stalling DNA replication forks. This could indirectly inhibit INO80E's function by disrupting the normal progression of replication. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
Olaparib inhibits PARP1, a protein involved in DNA repair. This could indirectly affect INO80E by increasing the demand for its DNA repair function and potentially exceeding its capacity. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide inhibits topoisomerase II, leading to DNA double-strand breaks. This could indirectly affect INO80E by increasing the demand for its DNA repair function. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-azacytidine incorporates into DNA and inhibits DNA methyltransferases, leading to hypomethylation of DNA. This could indirectly affect INO80E by altering the chromatin state and hindering its function. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
Romidepsin is a histone deacetylase inhibitor that alters the chromatin state, which could indirectly inhibit INO80E function. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $37.00 $112.00 $408.00 | ||
BIX-01294 inhibits G9a methyltransferase, leading to decreased H3K9 methylation, a marker for condensed chromatin. This could indirectly affect INO80E function by altering the chromatin state. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
Mithramycin A binds to DNA and inhibits transcription by RNA polymerase II. This could indirectly affect INO80E function by reducing the overall level of transcription, potentially leading to decreased replication events. | ||||||