INO80E Activators
The INO80E activators are a group of chemicals with diverse biochemical properties that can indirectly enhance the functional activity of the INO80E protein. These chemicals exert their effects by influencing various signaling pathways or biological processes that the INO80E protein is involved in. For instance, Staurosporine affects multiple pathways including the DNA damage response pathway. Given that INO80E is a part of the INO80 chromatin remodeling complex which is essential for this pathway, staurosporine can indirectly activate INO80E. Similarly, Thapsigargin increases cytosolic calcium, thereby influencing calcium-mediated signaling pathways that can indirectly activate INO80E.
Moreover, Roscovitine can halt cell cycle progression, increasing the requirement for INO80E activity in DNA repair and replication. On the other hand, Etoposide induces double-strand breaks in DNA, indirectly leading to enhanced functional activity of INO80E in the DNA repair pathway.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
A non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA). It leads to an increase in cytosolic calcium, which can indirectly activate INO80E by influencing the calcium-mediated signaling pathways. | ||||||
AICAR | 2627-69-2 | sc-200659 sc-200659A sc-200659B | 50 mg 250 mg 1 g | $65.00 $280.00 $400.00 | 48 | |
A cyclin-dependent kinase inhibitor that can halt cell cycle progression, potentially increasing the requirement for INO80E activity in DNA repair and replication. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor that can affect multiple signaling pathways. Given the role of INO80E in DNA repair and chromatin remodeling, this compound can potentially enhance the functional activity of the protein. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
An activator of sirtuins and has been shown to modulate chromatin remodeling, which can indirectly activate INO80E. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
An inhibitor of histone deacetylase, impacting chromatin structure and potentially influencing the activity of INO80E. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
An inhibitor of DNA methyltransferases, potentially affecting DNA methylation patterns and indirectly enhancing INO80E activity in chromatin remodeling. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
An inhibitor of histone deacetylase enzymes. It can influence chromatin structure, potentially affecting the activity of INO80E. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
A selective inhibitor of Rho-associated protein kinases. It can influence cytoskeletal dynamics, potentially indirectly enhancing the functional activity of INO80E. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
A tyrosine kinase inhibitor that can impact numerous signaling pathways and potentially lead to enhanced INO80E activity. | ||||||