INO80E Antibody (B-6): sc-515298
- INO80E Antibody (B-6) is a mouse monoclonal IgG1 κ INO80E antibody, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 51-130 mapping within an internal region of INO80E of human origin
- INO80E Antibody (B-6) is recommended for detection of INO80E of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-INO80E Antibody (B-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for INO80E Antibody (B-6) for WB applications. These reagents are now offered in bundles with INO80E Antibody (B-6) (see ordering information below).
QUICK LINKS
INO80E Antibody (B-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects INO80E protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). INO80E Antibody (B-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. INO80E protein, also known as CCDC95, is a crucial component of the INO80 chromatin-remodeling complex, which plays a significant role in regulating chromatin structure and function. This complex is essential for various nuclear processes, including transcription, DNA repair, and DNA replication, highlighting INO80E′s importance in maintaining genomic stability and proper gene expression. The INO80 complex is evolutionarily conserved from yeast to humans and is characterized by a unique split ATPase domain in its core ATPase subunit, which is vital for ATP-dependent chromatin remodeling activity. By altering the accessibility of DNA within chromatin, INO80E protein facilitates the dynamic regulation of gene expression and cellular responses to DNA damage, making INO80E a key player in cellular homeostasis and response to environmental stressors.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
INO80E Antibody (B-6) References:
- A protein complex containing the conserved Swi2/Snf2-related ATPase Swr1p deposits histone variant H2A.Z into euchromatin. | Kobor, MS., et al. 2004. PLoS Biol. 2: E131. PMID: 15045029
- A mammalian chromatin remodeling complex with similarities to the yeast INO80 complex. | Jin, J., et al. 2005. J Biol Chem. 280: 41207-12. PMID: 16230350
- INO80 subfamily of chromatin remodeling complexes. | Bao, Y. and Shen, X. 2007. Mutat Res. 618: 18-29. PMID: 17316710
- The Ino80 chromatin-remodeling enzyme regulates replisome function and stability. | Papamichos-Chronakis, M. and Peterson, CL. 2008. Nat Struct Mol Biol. 15: 338-45. PMID: 18376411
- Activator-dependent recruitment of SWI/SNF and INO80 during INO1 activation. | Ford, J., et al. 2008. Biochem Biophys Res Commun. 373: 602-6. PMID: 18593569
- The INO80 chromatin remodeling complex in transcription, replication and repair. | Conaway, RC. and Conaway, JW. 2009. Trends Biochem Sci. 34: 71-7. PMID: 19062292
- INO80-dependent chromatin remodeling regulates early and late stages of mitotic homologous recombination. | Tsukuda, T., et al. 2009. DNA Repair (Amst). 8: 360-9. PMID: 19095087
- Chromatin remodelling beyond transcription: the INO80 and SWR1 complexes. | Morrison, AJ. and Shen, X. 2009. Nat Rev Mol Cell Biol. 10: 373-84. PMID: 19424290
- Cooperation between the INO80 complex and histone chaperones determines adaptation of stress gene transcription in the yeast Saccharomyces cerevisiae. | Klopf, E., et al. 2009. Mol Cell Biol. 29: 4994-5007. PMID: 19620280
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
INO80E Antibody (B-6) | sc-515298 | 200 µg/ml | $322.00 | |||
INO80E Antibody (B-6): m-IgG Fc BP-HRP Bundle | sc-528018 | 200 µg Ab; 10 µg BP | $361.00 | |||
INO80E Antibody (B-6): m-IgG1 BP-HRP Bundle | sc-533391 | 200 µg Ab; 20 µg BP | $361.00 | |||
INO80E Antibody (B-6) AC | sc-515298 AC | 500 µg/ml, 25% agarose | $424.00 | |||
INO80E Antibody (B-6) HRP | sc-515298 HRP | 200 µg/ml | $322.00 | |||
INO80E Antibody (B-6) FITC | sc-515298 FITC | 200 µg/ml | $336.00 | |||
INO80E Antibody (B-6) PE | sc-515298 PE | 200 µg/ml | $349.00 | |||
INO80E Antibody (B-6) Alexa Fluor® 488 | sc-515298 AF488 | 200 µg/ml | $364.00 | |||
INO80E Antibody (B-6) Alexa Fluor® 546 | sc-515298 AF546 | 200 µg/ml | $364.00 | |||
INO80E Antibody (B-6) Alexa Fluor® 594 | sc-515298 AF594 | 200 µg/ml | $364.00 | |||
INO80E Antibody (B-6) Alexa Fluor® 647 | sc-515298 AF647 | 200 µg/ml | $364.00 | |||
INO80E Antibody (B-6) Alexa Fluor® 680 | sc-515298 AF680 | 200 µg/ml | $364.00 | |||
INO80E Antibody (B-6) Alexa Fluor® 790 | sc-515298 AF790 | 200 µg/ml | $364.00 |