INO80C Inhibitors
INO80C inhibitors predominantly focus on modulating the chromatin context or the DNA damage response, thereby indirectly influencing the activity and recruitment of the INO80 complex. Chemicals like Trichostatin A or SAHA that inhibit histone deacetylases lead to increased histone acetylation, altering the chromatin structure in a way that affects the ability of INO80C and its complex to bind or remodel chromatin. Similarly, agents like 5-aza-2'-deoxycytidine change the DNA methylation landscape, which can influence the recruitment of chromatin-associated proteins, including INO80C.
On the other hand, the DNA damage response is a critical aspect of INO80C's function. Compounds such as Olaparib and NU7441 target components of the DNA damage repair machinery. These chemicals might result in persistent DNA lesions or altered repair dynamics that can influence the recruitment and activity of chromatin remodelers, including the INO80 complex.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
HDAC inhibitor that prevents deacetylation of histones. Altered histone acetylation can affect INO80C's chromatin remodeling function. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
DNA methyltransferase inhibitor that changes the DNA methylation landscape, potentially influencing the recruitment of INO80C to chromatin. | ||||||
Olaparib | 763113-22-0 | sc-302017 sc-302017A sc-302017B | 250 mg 500 mg 1 g | $210.00 $305.00 $495.00 | 10 | |
PARP inhibitor affecting DNA damage repair pathways. Can modulate the DNA repair events where INO80C is required. | ||||||
NU 7441 | 503468-95-9 | sc-208107 | 5 mg | $357.00 | 10 | |
DNA-PK inhibitor that dampens the DNA double-strand break repair. Since INO80C participates in DNA repair, its function can be altered here. | ||||||
C646 | 328968-36-1 | sc-364452 sc-364452A | 10 mg 50 mg | $265.00 $944.00 | 5 | |
p300/CBP histone acetyltransferase inhibitor. Altered histone acetylation landscapes can influence INO80C's remodeling roles. | ||||||
A-485 | 1889279-16-6 | sc-507493 | 5 mg | $275.00 | ||
p300/CBP histone acetyltransferase inhibitor. By changing histone acetylation, it indirectly modulates INO80C's function on chromatin. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
Bromodomain inhibitor, affecting recognition of acetylated histones. This can change the chromatin context for INO80C. | ||||||
DRB | 53-85-0 | sc-200581 sc-200581A sc-200581B sc-200581C | 10 mg 50 mg 100 mg 250 mg | $43.00 $189.00 $316.00 $663.00 | 6 | |
Transcription inhibitor that blocks RNA polymerase II elongation. Affecting transcription could indirectly influence INO80C recruitment. | ||||||
ICRF-193 | 21416-68-2 | sc-200889 sc-200889A | 1 mg 5 mg | $341.00 $927.00 | 7 | |
Topoisomerase II inhibitor. Impacts DNA topology which can indirectly influence the function of chromatin remodelers like INO80C. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $133.00 $275.00 | 37 | |
HDAC inhibitor that affects histone acetylation. Altered histone marks can change the recruitment or activity of INO80C. | ||||||