INO80C Activators
The chemicals classified as INO80C Activators are agents that can alter the chromatin state or DNA integrity, thus requiring the compensatory activity of chromatin remodeling complexes like INO80, which contains the INO80C subunit. These compounds exert their effects through various mechanisms that influence the acetylation status of histones, DNA methylation, DNA damage responses, and other processes that could necessitate the action of INO80C as part of the cellular response.
For instance, HDAC inhibitors such as Trichostatin A, SAHA, and Sodium Butyrate increase acetylation levels of histones, which is often associated with a more open chromatin structure and can thus facilitate the access and function of chromatin remodelers. Similarly, DNA intercalators like Chloroquine and inhibitors of DNA repair enzymes like Camptothecin introduce disturbances in the chromatin or DNA that may indirectly invoke a greater need for INO80 complex-mediated remodeling to restore genomic integrity. Additionally, signaling modifiers such as Lithium Chloride or hormone analogs like β-Estradiol can induce broader changes in gene expression profiles, altering the recruitment and activity of the INO80 complex.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate acts as an HDAC inhibitor, leading to increased histone acetylation and potentially enhanced chromatin accessibility. This could elevate the activity of the INO80 complex. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide functions as an inhibitor of sirtuins, which are NAD+-dependent deacetylases. Inhibition of sirtuins can lead to a rise in acetylated histones, thereby possibly enhancing the activity of chromatin remodeling complexes like INO80. | ||||||
β-Estradiol | 50-28-2 | sc-204431 sc-204431A | 500 mg 5 g | $62.00 $178.00 | 8 | |
β-Estradiol can modulate gene expression by engaging estrogen receptors which can lead to chromatin remodeling. This could necessitate the action of chromatin remodelers such as INO80C for transcriptional regulation. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine is known to inhibit phosphodiesterases leading to an increase in cAMP, which affects a variety of signaling pathways. It also can interfere with DNA repair mechanisms, which may influence the recruitment of DNA repair proteins, including the INO80 complex. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin is a topoisomerase I inhibitor that induces DNA breaks. The resulting need for DNA repair might indirectly increase the activity of the INO80 complex to facilitate the repair process, potentially affecting INO80C. | ||||||
L-Mimosine | 500-44-7 | sc-201536A sc-201536B sc-201536 sc-201536C | 25 mg 100 mg 500 mg 1 g | $35.00 $86.00 $216.00 $427.00 | 8 | |
Mimosine acts as an inhibitor of DNA replication which could lead to a stress response necessitating chromatin remodeling. This might indirectly enhance the activity of chromatin remodeling complexes including INO80C. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride can affect the Wnt signaling pathway and glycogen synthase kinase-3 (GSK-3) activity. By influencing these pathways, there may be a secondary effect on chromatin structure and gene expression that could involve the INO80 complex. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
17-AAG is an Hsp90 inhibitor that can affect the stability and function of several client proteins. If components of the INO80 complex are Hsp90 clients, 17-AAG might indirectly increase INO80C stability or activity by affecting the complex's assembly or function. | ||||||